Serological Evidence for Non-Lethal Exposures of Mongolian Wild Birds to Highly Pathogenic Avian Influenza H5N1 Virus

被引:15
|
作者
Gilbert, Martin [1 ,2 ]
Koel, Bjorn F. [3 ]
Bestebroer, Theo M. [3 ]
Lewis, Nicola S. [4 ]
Smith, Derek J. [4 ]
Fouchier, Ron A. M. [3 ]
机构
[1] Wildlife Conservat Soc, 2300 Southern Blvd, Bronx, NY 10460 USA
[2] Univ Glasgow, Coll Med Vet & Life Sci, Boyd Orr Ctr Populat & Ecosyst Hlth, Glasgow G12 8QQ, Lanark, Scotland
[3] Erasmus MC, Dept Virosci, NL-3015 GE Rotterdam, Netherlands
[4] Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England
来源
PLOS ONE | 2014年 / 9卷 / 12期
基金
美国国家卫生研究院; 英国生物技术与生命科学研究理事会;
关键词
A VIRUSES; EXPERIMENTAL-INFECTION; MIGRATORY WATERFOWL; GENETIC EVOLUTION; NORTHERN EUROPE; ASIAN LINEAGE; HONG-KONG; ANTIBODIES; GEESE; DUCKS;
D O I
10.1371/journal.pone.0113569
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Surveillance for highly pathogenic avian influenza viruses (HPAIV) in wild birds is logistically demanding due to the very low rates of virus detection. Serological approaches may be more cost effective as they require smaller sample sizes to identify exposed populations. We hypothesized that antigenic differences between classical Eurasian H5 subtype viruses (which have low pathogenicity in chickens) and H5N1 viruses of the Goose/Guangdong/96 H5 lineage (which are HPAIV) may be used to differentiate populations where HPAIVs have been circulating, from those where they have not. To test this we performed hemagglutination inhibition assays to compare the reactivity of serum samples from wild birds in Mongolia (where HPAIV has been circulating, n= 1,832)and Europe (where HPAIV has been rare or absent, n=497) to a panel of reference viruses including classical Eurasian H5 (of low pathogenicity), and five HPAIV H5N1 antigens of the Asian lineage A/Goose/Guangdong/1/96. Antibody titres were detected against at least one of the test antigens for 182 Mongolian serum samples (total seroprevalence of 0.10, n=1,832, 95% adjusted Wald confidence limits of 0.09-0.11) and 25 of the European sera tested (total seroprevalence of 0.05, n=497, 95% adjusted Wald confidence limits of 0.03-0.07). A bias in antibody titres to HPAIV antigens was found in the Mongolian sample set (22/182) that was absent in the European sera (0/25). Although the interpretation of serological data from wild birds is complicated by the possibility of exposure to multiple strains, and variability in the timing of exposure, these findings suggest that a proportion of the Mongolian population had survived exposure to HPAIV, and that serological assays may enhance the targeting of traditional HPAIV surveillance toward populations where isolation of HPAIV is more likely.
引用
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页数:15
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