Transannular dipolar cycloaddition as an approach towards the synthesis of the core ring system of the sarain alkaloids

被引：16

作者：

Franklin, Andrew I. ^{[1
]}

Bensa, David ^{[1
]}

Adams, Harry ^{[1
]}

Coldham, Iain ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 06期

基金：

英国工程与自然科学研究理事会;

关键词：

ENANTIOSELECTIVE TOTAL-SYNTHESIS; TRICYCLIC CORE; ASYMMETRIC CONSTRUCTION; CLOSING METATHESIS; AZOMETHINE YLIDES; A CORE; INTERMEDIATE; SKELETON;

D O I：

10.1039/c0ob01019g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Intramolecular transannular dipolar cycloaddition was investigated as a key step in a synthetic approach to the core of the sarain alkaloids; although the use of an azomethine ylide was unsuccessful with the chosen aldehyde substrate, cycloaddition with a nitrone did give the alternative regioisomeric bridged cycloadduct.

引用

页码：1901 / 1907

页数：7

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