Factors Associated with White Fat Browning: New Regulators of Lipid Metabolism

被引：19
|
作者：
Zhang, Peiwen [1 ,2 ]
He, Yuxu [1 ,2 ]
Wu, Shuang [1 ,2 ]
Li, Xinrong [1 ,2 ]
Lin, Xutao [1 ,2 ]
Gan, Mailin [1 ,2 ]
Chen, Lei [1 ,2 ]
Zhao, Ye [1 ,2 ]
Niu, Lili [1 ,2 ]
Zhang, Shunhua [1 ,2 ]
Li, Xuewei [1 ,2 ]
Zhu, Li [1 ,2 ]
Shen, Linyuan [1 ,2 ]
机构：
[1] Sichuan Agr Univ, Coll Anim Sci & Technol, Chengdu 611130, Peoples R China
[2] Sichuan Agr Univ, Farm Anim Genet Resources Explorat & Innovat Key, Chengdu 611130, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 14期
基金：
中国国家自然科学基金;
关键词：
white fat; brown fat; obesity; epigenetic; fat thermogenesis; BETA-ADRENERGIC STIMULATION; GROWTH-FACTOR; 21; P38 MAP KINASE; ADIPOSE-TISSUE; UNCOUPLING PROTEIN-1; MITOCHONDRIAL-FUNCTION; NATRIURETIC PEPTIDES; SUBCUTANEOUS FAT; UCP1; EXPRESSION; GUT MICROBIOTA;
D O I：
10.3390/ijms23147641
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mammalian adipose tissue can be divided into white and brown adipose tissue based on its colour, location, and cellular structure. Certain conditions, such as sympathetic nerve excitement, can induce the white adipose adipocytes into a new type of adipocytes, known as beige adipocytes. The process, leading to the conversion of white adipocytes into beige adipocytes, is called white fat browning. The dynamic balance between white and beige adipocytes is closely related to the body's metabolic homeostasis. Studying the signal transduction pathways of the white fat browning might provide novel ideas for the treatment of obesity and alleviation of obesity-related glucose and lipid metabolism disorders. This article aimed to provide an overview of recent advances in understanding white fat browning and the role of BAT in lipid metabolism.
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页数：30
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