Factors Associated with White Fat Browning: New Regulators of Lipid Metabolism

被引：19

作者：

Zhang, Peiwen ^{[1
,2
]}

He, Yuxu ^{[1
,2
]}

Wu, Shuang ^{[1
,2
]}

Li, Xinrong ^{[1
,2
]}

Lin, Xutao ^{[1
,2
]}

Gan, Mailin ^{[1
,2
]}

Chen, Lei ^{[1
,2
]}

Zhao, Ye ^{[1
,2
]}

Niu, Lili ^{[1
,2
]}

Zhang, Shunhua ^{[1
,2
]}

Li, Xuewei ^{[1
,2
]}

Zhu, Li ^{[1
,2
]}

Shen, Linyuan ^{[1
,2
]}

机构：

[1] Sichuan Agr Univ, Coll Anim Sci & Technol, Chengdu 611130, Peoples R China

[2] Sichuan Agr Univ, Farm Anim Genet Resources Explorat & Innovat Key, Chengdu 611130, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 14期

基金：

中国国家自然科学基金;

关键词：

white fat; brown fat; obesity; epigenetic; fat thermogenesis; BETA-ADRENERGIC STIMULATION; GROWTH-FACTOR; 21; P38 MAP KINASE; ADIPOSE-TISSUE; UNCOUPLING PROTEIN-1; MITOCHONDRIAL-FUNCTION; NATRIURETIC PEPTIDES; SUBCUTANEOUS FAT; UCP1; EXPRESSION; GUT MICROBIOTA;

D O I：

10.3390/ijms23147641

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mammalian adipose tissue can be divided into white and brown adipose tissue based on its colour, location, and cellular structure. Certain conditions, such as sympathetic nerve excitement, can induce the white adipose adipocytes into a new type of adipocytes, known as beige adipocytes. The process, leading to the conversion of white adipocytes into beige adipocytes, is called white fat browning. The dynamic balance between white and beige adipocytes is closely related to the body's metabolic homeostasis. Studying the signal transduction pathways of the white fat browning might provide novel ideas for the treatment of obesity and alleviation of obesity-related glucose and lipid metabolism disorders. This article aimed to provide an overview of recent advances in understanding white fat browning and the role of BAT in lipid metabolism.

引用

页数：30

共 50 条

[1] Glycogen as a Regulator of White Fat Browning A new study on the relationship between glycogen metabolism and thermogenesis
Choi, Seri
MOLECULES AND CELLS, 2022, 45 (04) : 177 - 179
[2] Epigenetic Regulators of White Adipocyte Browning
Nanduri, Ravikanth
EPIGENOMES, 2021, 5 (01)
[3] Browning of White Fat: Novel Insight Into Factors, Mechanisms, and Therapeutics
Jeremic, Nevena
Chaturvedi, Pankaj
Tyagi, Suresh C.
JOURNAL OF CELLULAR PHYSIOLOGY, 2017, 232 (01) : 61 - 68
[4] Modulation of angiogenic switch in reprogramming browning and lipid metabolism in white adipocytes
Sreekumar, Sreelekshmi
Gangaraj, Karyath Palliyath
Kiran, Manikantan Syamala
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2024, 1869 (01):
[5] Transcription Regulators and Hormones Involved in the Development of Brown Fat and White Fat Browning: Transcriptional and Hormonal Control of Brown/Beige Fat Development
Zhang, Jianmei
Wu, Huixiao
Ma, Shizhan
Jing, Fei
Yu, Chunxiao
Gao, Ling
Zhao, Jiajun
PHYSIOLOGICAL RESEARCH, 2018, 67 (03) : 347 - 362
[6] Browning of white fat: What is the driving force?
Eckel, Juergen
ACTA PHYSIOLOGICA, 2015, 215 : 29 - 29
[7] Thyroid hormones induce browning of white fat
Martinez-Sanchez, Noelia
Moreno-Navarrete, Jose M.
Contreras, Cristina
Rial-Pensado, Eva
Ferno, Johan
Nogueiras, Ruben
Dieguez, Carlos
Fernandez-Real, Jose-Manuel
Lopez, Miguel
JOURNAL OF ENDOCRINOLOGY, 2017, 232 (02) : 351 - 362
[8] Lipid Regulators of Thermogenic Fat Activation
Park, Hongsuk
He, Anyuan
Lodhi, Irfan J.
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2019, 30 (10): : 710 - 723
[9] β-Hydroxy-β-methyl Butyrate Regulates the Lipid Metabolism, Mitochondrial Function, and Fat Browning of Adipocytes
Duan, Geyan
Zheng, Changbing
Yu, Jiayi
Zhang, Peiwen
Wan, Mengliao
Zheng, Jie
Duan, Yehui
NUTRIENTS, 2023, 15 (11)
[10] Dynamic changes in lipid droplet-associated proteins in the "browning" of white adipose tissues
Barneda, David
Frontini, Andrea
Cinti, Saverio
Christian, Mark
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2013, 1831 (05): : 924 - 933

← 1 2 3 4 5 →