Intracerebral hemorrhage in mouse models: therapeutic interventions and functional recovery

被引：16

作者：

Kathirvelu, Balachandar ^{[1
]}

Carmichael, S. Thomas ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA

来源：

METABOLIC BRAIN DISEASE | 2015年 / 30卷 / 02期

关键词：

ICH; Collagenase; Autologous blood; Functional recovery; MIDBRAIN DOPAMINERGIC-NEURONS; ACID RECEPTOR STIMULATION; RETINOIC ACID; PROLONGED HYPOTHERMIA; NEUROTROPHIC FACTOR; MICROGLIAL ACTIVATION; STROKE-COUNCIL; UP-REGULATION; BRAIN-INJURY; TNF-ALPHA;

D O I：

10.1007/s11011-014-9559-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There has been strong pre-clinical research on mechanisms of initial cell death and tissue injury in intracerebral hemorrhage (ICH). This data has led to the evaluation of several therapeutics for neuroprotection or the mitigation of early tissue damage. Most of these studies have been done in the rat. Also, there has been little study of the mechanisms of tissue repair and recovery. This review examines the testing of candidate therapeutics in mouse models of ICH for their effect on tissue protection and repair. This review will help the readers compare it to the extensively researched rat model of ICH and thus enhance work that are pending in mouse model.

引用

页码：449 / 459

页数：11

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