Green Synthesis of Fused Polycyclic Pyrazolo[3,4-b][1,6]naphthyridine Derivatives in Ionic Liquids via Three-Component Reaction

被引：5
|
作者：
Feng, Bin-Bin [1 ]
Zhang, Mei-Mei [1 ]
Wang, Xiang-Shan [1 ]
机构：
[1] Jiangsu Normal Univ, Sch Chem & Chem Engn, Jiangsu Key Lab Green Synth Funct Mat, Xuzhou 221116, Jiangsu, Peoples R China
来源：
POLYCYCLIC AROMATIC COMPOUNDS | 2016年 / 36卷 / 04期
关键词：
ionic liquids; piperidine-2; 4-dione; pyrazolonaphthyridine; synthesis; INHIBITORS; ACTIVATION; EFFICIENT; IODINE;
D O I：
10.1080/10406638.2015.1014969
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A green synthesis of fused polycyclic 4-aryl-3-methyl-1-phenyl-7,8-dihydro- 1H-pyrazolo[3,4-b][1,6]naphthyridin-5(4H)-one derivatives is described in ionic liquids. Under the protection of nitrogen, this three-component reaction including aromatic aldehyde, 3-methyl-1-phenyl-1H-pyrazol-5-amine, and piperidine-2,4-dione gives un-aromatized products in high yields. This new procedure to pyrazolonaphthyridines has the advantages of one pot reaction, milder reaction conditions, high yields, and is environmentally benign.
引用
收藏
页码：478 / 489
页数：12
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