Gender-Specific Association of Serum Uric Acid and Pulmonary Function: Data from the Korea National Health and Nutrition Examination Survey

被引:10
|
作者
Jeong, Hyemin [1 ]
Baek, Sun-Young [2 ]
Kim, Seon-Woo [2 ]
Park, Eun-Jung [3 ]
Kim, Hyungjin [4 ]
Lee, Jaejoon [4 ]
Jeon, Chan-Hong [1 ]
机构
[1] Soonchunhyang Univ, Bucheon Hosp, Coll Med, Div Rheumatol,Dept Internal Med, 170 Jomaru Ro, Bucheon 14584, South Korea
[2] Samsung Med Ctr, Biostat & Clin Epidemiol Ctr, 81 Irwon Ro, Seoul 06351, South Korea
[3] Natl Med Ctr, Dept Internal Med, Div Rheumatol, 245 Eulji Ro, Seoul 04564, South Korea
[4] Sungkyunkwan Univ, Dept Internal Med, Div Rheumatol, Sch Med,Samsung Med Ctr, 81 Irwon Ro, Seoul 06351, South Korea
来源
MEDICINA-LITHUANIA | 2021年 / 57卷 / 09期
关键词
uric acid; nutrition surveys; lung; respiratory function tests; SMOOTH-MUSCLE-CELLS; OXIDATIVE STRESS; HYPOXIA; RISK; GOUT;
D O I
10.3390/medicina57090953
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and Objectives: Hyperuricemia is associated with several comorbidities. The association between uric acid (UA) and pulmonary function is still a controversial issue. This study evaluated the gender-specific association of serum UA and pulmonary function. Materials and Methods: A total of 3177 (weighted n = 19,770,902) participants aged 40 years or older were selected from the 2016 Korean National Health and Nutrition Examination Survey and included. Results: Female participants with hyperuricemia were older than participants with normouricemia. Body mass index (BMI), mean arterial pressure (MAP), hemoglobin A1c (HbA1c), and estimated glomerular filtration rate (eGFR) were significantly associated with UA levels in both males and females. Hyperuricemia and increase in UA quartile were significantly associated with decreased forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) in females after adjustment for age, income, region, education, marital status, alcohol consumption, smoking, BMI, MAP, HbA1c, and eGFR. There was no significant association between UA levels and lung function in males. After additional adjustment for respiratory disease including pulmonary tuberculosis, asthma, and lung cancer, the association between hyperuricemia and decreased FEV1 and FVC in females was revealed. Conclusions: Hyperuricemia was associated with decreased FVE1 and FVC in the female general population.
引用
收藏
页数:10
相关论文
共 50 条
  • [41] Serum Zinc Status and Its Association with Allergic Sensitization: The Fifth Korea National Health and Nutrition Examination Survey
    Seo, Hyun-Min
    Kim, Yeong Ho
    Lee, Ji Hyun
    Kim, Joung Soo
    Park, Young Min
    Lee, Jun Young
    [J]. SCIENTIFIC REPORTS, 2017, 7
  • [42] Data Resource Profile: The Korea National Health and Nutrition Examination Survey (KNHANES)
    Kweon, Sanghui
    Kim, Yuna
    Jang, Myoung-jin
    Kim, Yoonjung
    Kim, Kirang
    Choi, Sunhye
    Chun, Chaemin
    Khang, Young-Ho
    Oh, Kyungwon
    [J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2014, 43 (01) : 69 - 77
  • [43] Association Between Vestibular and Cognitive Function in US Adults: Data From the National Health and Nutrition Examination Survey
    Semenov, Yevgeniy R.
    Bigelow, Robin T.
    Xue, Qian-Li
    du Lac, Sascha
    Agrawal, Yuri
    [J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2016, 71 (02): : 243 - 250
  • [44] Gender Disparity in the Prevalence of Metabolic Syndrome in Korea: Results from the Korea National Health and Nutrition Examination Survey, 2012
    Im, Mee Young
    Seomun, Gyeong Ae
    [J]. JOURNAL OF DIABETES & METABOLISM, 2015, 6 (01)
  • [45] Association of nocturia and cardiovascular disease: Data from the National Health and Nutrition Examination Survey
    Moon, Shinje
    Yu, Sung Hoon
    Chung, Hye Soo
    Kim, Yoon Jung
    Yu, Jae Myung
    Kim, Sung Jin
    Kwon, Ohseong
    Lee, Young Goo
    Cho, Sung Tae
    [J]. NEUROUROLOGY AND URODYNAMICS, 2021, 40 (06) : 1569 - 1575
  • [46] Prevalence of Otolaryngologic Diseases in South Korea: Data from the Korea National Health and Nutrition Examination Survey 2008
    Cho, Yang-Sun
    Choi, Seung-Ho
    Park, Kyoung Ho
    Park, Hong Ju
    Kim, Jeong-Whun
    Moon, Il Joon
    Rhee, Chae-Seo
    Kim, Kyung Soo
    Sun, Dong-Il
    Lee, Seung Hwan
    Koo, Ja-Won
    Koh, Yoon Woo
    Lee, Kun Hee
    Lee, Seung Won
    Oh, Kyung Won
    Pyo, Eun Young
    Lee, Ari
    Kim, Young Taek
    Lee, Chul Hee
    [J]. CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY, 2010, 3 (04) : 183 - 193
  • [47] Prevalence and risk factors for reduced pulmonary function in diabetic patients: The Korea National Health and Nutrition Examination Survey
    Kim, Hee Yeon
    Sohn, Tae Seo
    Seok, Hannah
    Yeo, Chang Dong
    Kim, Young Soo
    Song, Jae Yen
    Lee, Young Bok
    Lee, Dong-Hee
    Lee, Jae-Im
    Lee, Tae-Kyu
    Jeong, Seong Cheol
    Hong, Mihee
    Chae, Hiun Suk
    [J]. KOREAN JOURNAL OF INTERNAL MEDICINE, 2017, 32 (04): : 682 - 689
  • [48] Gender-specific association of serum uric acid with metabolic syndrome and its components in juvenile obesity
    Krzystek-Korpacka, Malgorzata
    Patryn, Eliza
    Kustrzeba-Wojcicka, Irena
    Chrzanowska, Joanna
    Gamian, Andrzej
    Noczynska, Anna
    [J]. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2011, 49 (01) : 129 - 136
  • [49] Prevalence of Periodontitis and Its Association with Reduced Pulmonary Function: Results from the Korean National Health and Nutrition Examination Survey
    Lee, Euni
    Lee, Seok-Woo
    [J]. MEDICINA-LITHUANIA, 2019, 55 (09):
  • [50] Association between exposure to fine particulate matter and kidney function: Results from the Korea National Health and Nutrition Examination Survey
    Oh, Jongmin
    Ye, Shinhee
    Kang, Duk-Hee
    Ha, Eunhee
    [J]. ENVIRONMENTAL RESEARCH, 2022, 212