Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup

被引：14

作者：

Raina, Rupesh ^{[1
,2
]}

Grewal, Manpreet K. ^{[2
]}

Blackford, Martha ^{[3
]}

Symons, Jordan M. ^{[4
]}

Somers, Michael J. G. ^{[5
]}

Licht, Christoph ^{[6
]}

Basu, Rajit K. ^{[7
]}

Sethi, Sidharth Kumar ^{[8
]}

Chand, Deepa ^{[9
]}

Kapur, Gaurav ^{[10
]}

McCulloch, Mignon ^{[11
]}

Bagga, Arvind ^{[12
]}

Krishnappa, Vinod ^{[2
]}

Yap, Hui-Kim ^{[13
]}

Tavares, Marcelo de Sousa ^{[14
]}

Bunchman, Timothy E. ^{[15
]}

Bestic, Michelle ^{[3
]}

Warady, Bradley A. ^{[16
]}

de Ferris, Maria Diaz-Gonzalez ^{[17
]}

机构：

[1] Akron Childrens Hosp, Dept Nephrol, Akron, OH 44308 USA

[2] Cleveland Clin Akron Gen, Akron Nephrol Associates, 224 W Exchange St, Akron, OH 44302 USA

[3] Akron Childrens Hosp, Div Clin Pharmacol & Toxicol, Akron, OH 44308 USA

[4] Univ Washington, Sch Med, Dept Pediat, Seattle, WA 98195 USA

[5] Boston Childrens Hosp, Div Nephrol, Boston, MA USA

[6] Univ Toronto, Dept Pediat, Div Nephrol, Toronto, ON, Canada

[7] Childrens Healthcare Atlanta, Dept Pediat Crit Care Med, Atlanta, GA USA

[8] Med Hosp, Medanta, Kidney & Urol Inst, Pediat Nephrol & Pediat Kidney Transplantat, Gurgaon, India

[9] Washington Univ, Sch Med, Div Pediat Nephrol, St Louis, MO USA

[10] Wayne State Univ, Childrens Hosp Michigan, Dept Pediat Nephrol, Detroit, MI USA

[11] Univ Cape Town, Red Cross War Mem Childrens Hosp, Cape Town, South Africa

[12] All India Inst Med Sci, Div Paediat Nephrol, New Delhi, India

[13] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pediat, Singapore, Singapore

[14] Univ Nove Julho, Med Sch, Dept Paediat, Sao Paulo, Brazil

[15] Virginia Commonwealth Univ, Childrens Hosp Richmond, Pediat Nephrol & Transplantat, Richmond, VA USA

[16] Childrens Mercy Kansas City, Div Pediat Nephrol, Kansas City, MO USA

[17] Univ North Carolina Chapel Hill, Dept Pediat, Chapel Hill, NC USA

来源：

PEDIATRIC NEPHROLOGY | 2019年 / 34卷 / 11期

关键词：

Intoxications; Renal replacement therapies; Children; Hemodialysis; PASS ALBUMIN DIALYSIS; EXTRACORPOREAL TREATMENT; ETHYLENE-GLYCOL; LACTIC-ACIDOSIS; METFORMIN INTOXICATION; CHARCOAL HEMOPERFUSION; POISONING RECOMMENDATIONS; CARBAMAZEPINE OVERDOSE; ACETAMINOPHEN OVERDOSE; VANCOMYCIN OVERDOSE;

D O I：

10.1007/s00467-019-04319-2

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background Intentional or unintentional ingestions among children and adolescents are common. There are a number of ingestions amenable to renal replacement therapy (RRT). Methods We systematically searched PubMed/Medline, Embase, and Cochrane databases for literature regarding drugs/intoxicants and treatment with RRT in pediatric populations. Two experts from the PCRRT (Pediatric Continuous Renal Replacement Therapy) workgroup assessed titles, abstracts, and full-text articles for extraction of data. The data from the literature search was shared with the PCRRT workgroup and two expert toxicologists, and expert panel recommendations were developed. Results and Conclusions We have presented the recommendations concerning the use of RRTs for treatment of intoxications with toxic alcohols, lithium, vancomycin, theophylline, barbiturates, metformin, carbamazepine, methotrexate, phenytoin, acetaminophen, salicylates, valproic acid, and aminoglycosides.

引用

页码：2427 / 2448

页数：22

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