Sensitive and selective voltammetric oxidation and determination of an antiemetic drug using gold electrode and its biomedical applications

In this study, we investigated the voltammetric oxidation and determination of an antiemetic drug, metoclo- pramide hydrochloride at gold electrode using cyclic, linear sweep and differential pulse voltammetric (DPV) techniques. The anodic peak was characterized and the process was diffusion -controlled. The influence of cur- rent on pH, scan rate, concentration was studied to optimize the experimental conditions. The number of electrons transferred was calculated and plausible oxidation mechanism was proposed. The ability of gold electrode to determine trace amount of MCP was studied using DPV. Limit of detection and quantification was calculated under the optimized conditions. For the analytical applications, pharmaceutical formulation and human urine sample analysis were performed. Various excipients were used to investigate their interference in the analytical application and it was found that the proposed method can be adopted for clinical trials, quality control and real sample analysis.