Three new isocoumarin derivatives from the mangrove endophytic fungus Penicillium sp. YYSJ-3

被引：16
|
作者：
Qiu Pei [1 ]
Cai Run-Lin [1 ]
Li Lin [1 ]
She Zhi-Gang [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Peoples R China
[2] South China Sea Bioresource Exploitat & Utilizat, Guangzhou 510006, Peoples R China
来源：
CHINESE JOURNAL OF NATURAL MEDICINES | 2020年 / 18卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Isocoumarin derivatives; Penicillium sp; Structure elucidation; alpha-Glucosidase inhibitory activity; BENZOFURANS;
D O I：
10.1016/S1875-5364(20)30031-5
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Three new isocoumarin derivatives, (S)-6,8-dihydroxy-5-(methoxymethyl)-3,7-dimethylisochroman-1-one (1), (S)-6,8-dihydroxy-3,5,7-trimethyl-isochroman-1-one (2) and (R)-2-chloro-3-(8-hydroxy-6-methoxy-1-oxo-1H-isochromen-3-yl) propyl acetate (3), along with four known compounds (4-7) were isolated from a mangrove endophytic fungus Penicillium sp. YYSJ-3. Their structures were established on the basis of the extensive spectroscopic data and HR-ESI-MS analysis. The absolute configurations of 1-3 were further determined by X-ray diffraction analysis and optical rotations. Compounds 3, 6 and 7 showed promising inhibitory activity against alpha-glucosidase, which were stronger than that of the positive control 1-deoxynojirimycin (IC50 141.2 mu mol.L-1).
引用
收藏
页码：256 / 260
页数：5
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