Retinoic Acid Related Orphan Receptor A (RORA) gene variants and risk of bladder cancer

被引：2
|
作者：
Rakhshan, Azadeh [1 ]
Omrani, Mir Davood [1 ,2 ]
Noroozi, Rezvan [2 ,3 ]
Taheri, Mohammad [4 ]
Ghafouri-Fard, Soudeh [2 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Urogenital Stem Cell Res Ctr, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Dept Med Genet, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Phytochem Res Ctr, Tehran, Iran
[4] Shahid Beheshti Univ Med Sci, Student Res Comm, Tehran, Iran
来源：
GENE REPORTS | 2019年 / 14卷
关键词：
Retinoic acid-related orphan receptors alpha; Polymorphism; Bladder cancer; GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY; REVEALS;
D O I：
10.1016/j.genrep.2018.11.005
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The retinoic acid-related orphan receptors alpha (RORA) is a member of nuclear receptors that act as ligand-dependent transcription factors. Single nucleotide polymorphisms (SNPs) within this gene have been associated with a number of human disorders including multiple sclerosis and autism spectrum disorder. In the present study, we genotyped two RORA SNPs (rs11639084 and rs4774388) in 122 Iranian patients with bladder cancer and 150 healthy subjects with no personal history of malignancy and no urinary system complications. There were no significant differences in allele, genotype and haplotype frequencies of these SNPs between cases and controls. In spite of role of these SNPs in the pathogenesis of some diseases, these variants are not possibly involved in bladder cancer risk in Iranian population.
引用
收藏
页码：22 / 24
页数：3
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