Rutinosylated Ferulic Acid Attenuates Food Allergic Response and Colitis by Upregulating Regulatory T Cells in Mouse Models

被引：16
|
作者：
Katayama, Shigeru [1 ,2 ]
Ohno, Fumiaki [1 ]
Mitani, Takakazu [1 ,2 ]
Akiyama, Hiroshi [3 ]
Nakamura, Soichiro [1 ]
机构：
[1] Shinshu Univ, Dept Biosci & Biotechnol, 8304 Minamiminowa, Ina, Nagano 3994598, Japan
[2] Shinshu Univ, Interdisciplinary Cluster Cutting Edge Res, 8304 Minamiminowa, Ina, Nagano 3994598, Japan
[3] Natl Inst Hlth Sci, Setagaya Ku, 1-18-1 Kamiyoga, Tokyo 1588501, Japan
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2017年 / 65卷 / 49期
关键词：
dendritic cells; ferulic acid; glycoside; immune tolerance; regulatory T cells; DEXTRAN SULFATE SODIUM; DENDRITIC CELLS; TGF-BETA; IMMUNOTHERAPY; DISEASE; INDUCTION; IMMUNITY; IL-10; ROLES;
D O I：
10.1021/acs.jafc.7b03933
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
The purpose of this study was to screen phytochemicals capable of inducing immune tolerance via enhanced transforming growth factor-beta 1 (TGF-beta 1) secretion and investigate their effects in a mouse model of food allergy and colitis. In a screening test using THP-1-derived dendritic cells, a significant increase in TGF-beta l levels was observed upon treatment with ferulic acid and its glycosides, among which ferulic acid rutinoside (FAR) induced the highest level of TGF-beta l secretion. Oral administration of FAR suppressed serum levels of immunoglobulin E and histamine in ovalbumin-sensitized mice and triggered the differentiation of regulatory T (Treg) cells. In comparison to the control, FAR treatment also induced stronger TGF-beta l secretion from splenic dendritic cells. FAR treatment attenuated dextran-sulfate-sodium-induced colitis in the model mice and induced Treg differentiation. These results suggest that FAR exerts potent immunomodulatory effects against allergic and intestinal inflammatory responses by inducing Treg differentiation.
引用
收藏
页码：10730 / 10737
页数：8
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