FOXM1: From cancer initiation to progression and treatment

被引：332
|
作者：
Koo, Chuay-Yeng [1 ]
Muir, Kyle W. [1 ]
Lam, Eric W. -F. [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, London W12 0NN, England
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2012年 / 1819卷 / 01期
关键词：
FOXM1; Chemotherapy; Cancer; Function; Regulation; M1 TRANSCRIPTION FACTOR; BREAST-CANCER; CELL-PROLIFERATION; OXIDATIVE STRESS; UP-REGULATION; HEPATOCELLULAR CARCINOMAS; NUCLEAR TRANSLOCATION; MULTIDRUG-RESISTANCE; DOWNSTREAM TARGET; HEPATOCYTE ENTRY;
D O I：
10.1016/j.bbagrm.2011.09.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Forkhead box protein M1 (FOXM1) transcription factor is a regulator of myriad biological processes, including cell proliferation, cell cycle progression, cell differentiation, DNA damage repair, tissue homeostasis, angiogenesis and apoptosis. Elevated FOXM1 expression is found in cancers of the liver, prostate, brain, breast, lung, colon, pancreas, skin, cervix, ovary, mouth, blood and nervous system, suggesting it has an integral role in tumorigenesis. Recent research findings also place FOXM1 at the centre of cancer progression and drug sensitivity. In this review the involvement of FOXM1 in various aspects of cancer, in particular its role and regulation within the context of cancer initiation, progression, and cancer drug response, will be summarised and discussed. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：28 / 37
页数：10
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