Transformed Mycosis Fungoides with a Cytotoxic T-Cell Phenotype

被引：0

作者：

Hiraiwa, Shinichiro ^{[1
]}

Hashimoto, Norisato ^{[2
]}

Ueda, Tomoki ^{[2
]}

Sugiyama, Tomoko ^{[1
]}

Yokoyama, Kenji ^{[2
]}

Matsuyama, Takashi ^{[3
]}

Tajiri, Takuma ^{[1
]}

Nakamura, Naoya ^{[4
]}

机构：

[1] Tokai Univ, Dept Pathol, Hachioji Hosp, Tokyo, Japan

[2] Tokai Univ, Dept Hematol & Oncol, Hachioji Hosp, Tokyo, Japan

[3] Tokai Univ, Dept Dermatol, Hachioji Hosp, Tokyo, Japan

[4] Tokai Univ, Dept Pathol, Sch Med, Isehara, Kanagawa, Japan

来源：

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2022年 / 30卷 / 07期

关键词：

mycosis fungoides; transformation; CD8-positive; cytotoxic; TCR; IMMUNOPHENOTYPIC SHIFT; LYMPHOMA; CD4(+); CD8(+);

D O I：

10.1177/10668969221084267

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Mycosis fungoides (MF) is a cutaneous T-cell lymphoma and occasionally undergo large cell transformation (transformed MF, TMF), resulting in a poorer clinical outcome. We describe a case of TMF with an immunophenotypic shift. MF showed the CD4 + CD8- T-cell phenotype, while TMF exhibited the CD4-CD8 + T-cell phenotype. Moreover, TMF expressed cytotoxic markers of TIA1 and Granzyme B. A PCR analysis of T-cell receptor genes revealed peak sizes that were the same in both biopsies, indicating that these two lymphomas were derived from the same clone.

引用

页码：816 / 822

页数：7

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