Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review

被引：43

作者：

Wang, Jing-Jing ^{[1
,2
]}

Sun, Wen ^{[1
,2
]}

Jia, Wei-Dong ^{[1
,2
]}

Bian, Ming ^{[1
,2
]}

Yu, Li-Jun ^{[1
,2
]}

机构：

[1] Inner Mongolia Minzu Univ, Inst Pharmaceut Chem & Pharmacol, Tongliao, Inner Mongolia, Peoples R China

[2] Inner Mongolia Key Lab Mongolian Med Pharmacol Ca, Tongliao, Inner Mongolia, Peoples R China

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2022年 / 37卷 / 01期

关键词：

1; 3; 4-oxadiazole; 2; Oxadiazole derivatives; synthesis; activity; MOLECULAR DOCKING; IN-VITRO; BIOLOGICAL EVALUATION; ANTIOXIDANT ACTIVITY; DESIGN; ANTIFUNGAL; ANTICANCER; DFT; ANTIBACTERIAL; POTENT;

D O I：

10.1080/14756366.2022.2115036

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxadiazole is a five-membered heterocyclic compound containing two nitrogen atoms and one oxygen atom. The 1,3,4-oxadiazole and 1,2,4-oxadiazole have favourable physical, chemical, and pharmacokinetic properties, which significantly increase their pharmacological activity via hydrogen bond interactions with biomacromolecules. In recent years, oxadiazole has been demonstrated to be the biologically active unit in a number of compounds. Oxadiazole derivatives exhibit antibacterial, anti-inflammatory, anti-tuberculous, anti-fungal, anti-diabetic and anticancer activities. In this paper, we report a series of compounds containing oxadiazole rings that have been published in the last three years only (2020-2022) as there was no report or their activities described in any article in 2019, which will be useful to scientists in research fields of organic synthesis, medicinal chemistry, and pharmacology.

引用

页码：2304 / 2319

页数：16

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