Nanoscale nuclear magnetic resonance with chemical resolution

被引：257
|
作者：
Aslam, Nabeel [1 ,2 ]
Pfender, Matthias [1 ,2 ]
Neumann, Philipp [1 ,2 ]
Reuter, Rolf [1 ,2 ]
Zappe, Andrea [1 ,2 ]
de Oliveira, Felipe Favaro [1 ,2 ]
Denisenko, Andrej [1 ,2 ]
Sumiya, Hitoshi [3 ]
Onoda, Shinobu [4 ]
Isoya, Junichi [5 ]
Wrachtrup, Joerg [1 ,6 ]
机构：
[1] Univ Stuttgart, Ctr Integrated Quantum Sci & Technol IQST, Pfaffenwaldring 57, D-70569 Stuttgart, Germany
[2] Univ Stuttgart, Phys Inst 3, Pfaffenwaldring 57, D-70569 Stuttgart, Germany
[3] Sumitomo Elect Ind, Itami, Hyogo 6640016, Japan
[4] Natl Inst Quantum & Radiol Sci & Technol, 1233 Watanuki, Takasaki, Gunma 3701292, Japan
[5] Univ Tsukuba, Research Ctr Knowledge Communities, Tsukuba, Ibaraki 3058550, Japan
[6] Max Planck Inst Solid State Res, Stuttgart, Germany
来源：
SCIENCE | 2017年 / 357卷 / 6346期
基金：
日本科学技术振兴机构; 日本学术振兴会;
关键词：
NMR-SPECTROSCOPY;
D O I：
10.1126/science.aam8697
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Nuclear magnetic resonance (NMR) spectroscopy is a key analytical technique in chemistry, biology, and medicine. However, conventional NMR spectroscopy requires an at least nanoliter-sized sample volume to achieve sufficient signal. We combined the use of a quantum memory and high magnetic fields with a dedicated quantum sensor based on nitrogen vacancy centers in diamond to achieve chemical shift resolution in H-1 and F-19 NMR spectroscopy of 20-zeptoliter sample volumes. We demonstrate the application of NMR pulse sequences to achieve homonuclear decoupling and spin diffusion measurements. The best measured NMR linewidth of a liquid sample was similar to 1 part per million, mainly limited by molecular diffusion. To mitigate the influence of diffusion, we performed high-resolution solid-state NMR by applying homonuclear decoupling and achieved a 20-fold narrowing of the NMR linewidth.
引用
收藏
页码：67 / 71
页数：5
相关论文
共 50 条
12345