Nanoscale nuclear magnetic resonance with chemical resolution

被引：257

作者：

Aslam, Nabeel ^{[1
,2
]}

Pfender, Matthias ^{[1
,2
]}

Neumann, Philipp ^{[1
,2
]}

Reuter, Rolf ^{[1
,2
]}

Zappe, Andrea ^{[1
,2
]}

de Oliveira, Felipe Favaro ^{[1
,2
]}

Denisenko, Andrej ^{[1
,2
]}

Sumiya, Hitoshi ^{[3
]}

Onoda, Shinobu ^{[4
]}

Isoya, Junichi ^{[5
]}

Wrachtrup, Joerg ^{[1
,6
]}

机构：

[1] Univ Stuttgart, Ctr Integrated Quantum Sci & Technol IQST, Pfaffenwaldring 57, D-70569 Stuttgart, Germany

[2] Univ Stuttgart, Phys Inst 3, Pfaffenwaldring 57, D-70569 Stuttgart, Germany

[3] Sumitomo Elect Ind, Itami, Hyogo 6640016, Japan

[4] Natl Inst Quantum & Radiol Sci & Technol, 1233 Watanuki, Takasaki, Gunma 3701292, Japan

[5] Univ Tsukuba, Research Ctr Knowledge Communities, Tsukuba, Ibaraki 3058550, Japan

[6] Max Planck Inst Solid State Res, Stuttgart, Germany

来源：

SCIENCE | 2017年 / 357卷 / 6346期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

NMR-SPECTROSCOPY;

D O I：

10.1126/science.aam8697

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nuclear magnetic resonance (NMR) spectroscopy is a key analytical technique in chemistry, biology, and medicine. However, conventional NMR spectroscopy requires an at least nanoliter-sized sample volume to achieve sufficient signal. We combined the use of a quantum memory and high magnetic fields with a dedicated quantum sensor based on nitrogen vacancy centers in diamond to achieve chemical shift resolution in H-1 and F-19 NMR spectroscopy of 20-zeptoliter sample volumes. We demonstrate the application of NMR pulse sequences to achieve homonuclear decoupling and spin diffusion measurements. The best measured NMR linewidth of a liquid sample was similar to 1 part per million, mainly limited by molecular diffusion. To mitigate the influence of diffusion, we performed high-resolution solid-state NMR by applying homonuclear decoupling and achieved a 20-fold narrowing of the NMR linewidth.

引用

页码：67 / 71

页数：5

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