Enantioselective Palladium-Catalyzed Oxidative β,β-Fluoroarylation of α,β-Unsaturated Carbonyl Derivatives

被引：61
|
作者：
Miro, Javier [1 ]
del Pozo, Carlos [1 ]
Toste, F. Dean [2 ]
Fustero, Santos [1 ,3 ]
机构：
[1] Univ Valencia, Dept Quim Organ, E-46100 Burjassot, Spain
[2] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
[3] Ctr Invest Principe Felipe, Lab Mol Organ, Valencia 46012, Spain
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 31期
关键词：
alkenes; fluorine; palladium; reaction mechanisms; synthetic methods; ALPHA-AMINO-ACIDS; C-H BONDS; BENZYLIC FLUORINATION; NUCLEOPHILIC FLUORINATION; SELECTIVE FLUORINATION; REDUCTIVE ELIMINATION; PHASE-TRANSFER; BORONIC ACIDS; FLUORIDE; ALKENES;
D O I：
10.1002/anie.201603046
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The site-selective palladium-catalyzed three-component coupling of deactivated alkenes, arylboronic acids, and N-fluorobenzenesulfonimide is disclosed herein. The developed methodology establishes a general, modular, and step-economical approach to the stereoselective beta-fluorination of alpha,beta-unsaturated systems.
引用
收藏
页码：9045 / 9049
页数：5
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