Synthesis of a (B12H11S)2- containing glucuronoside as potential prodrug for BNCT

被引：22
|
作者：
Lechtenberg, B [1 ]
Gabel, D [1 ]
机构：
[1] Univ Bremen, Dept Chem, D-28334 Bremen, Germany
来源：
JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2005年 / 690卷 / 11期
关键词：
BNCT; prodrug; BSH; glucuronic acid;
D O I：
10.1016/j.jorganchem.2005.01.042
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A B12H11SH2- containing glycoside of glucuronic acid has been prepared, for possible use as prodrug in BNCT. The synthesis was carried out by the Koenigs-Knorr reaction of the acetylated glucopyranosyluronate bromide with the nucleophile cyanoethylthioundecahydro-closo-dodecaborate(2-). After removal of the cyanoethyl-group, deacetylation and saponification of the reaction product tris(tetramethylammonium)-[S-(beta-D-glucuronate)-thio] undecahydro-closo-dodecaborate(3-) could be prepared. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：2780 / 2782
页数：3
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