Synthesis of a (B12H11S)2- containing glucuronoside as potential prodrug for BNCT

被引：22

作者：

Lechtenberg, B ^{[1
]}

Gabel, D ^{[1
]}

机构：

[1] Univ Bremen, Dept Chem, D-28334 Bremen, Germany

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2005年 / 690卷 / 11期

关键词：

BNCT; prodrug; BSH; glucuronic acid;

D O I：

10.1016/j.jorganchem.2005.01.042

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A B12H11SH2- containing glycoside of glucuronic acid has been prepared, for possible use as prodrug in BNCT. The synthesis was carried out by the Koenigs-Knorr reaction of the acetylated glucopyranosyluronate bromide with the nucleophile cyanoethylthioundecahydro-closo-dodecaborate(2-). After removal of the cyanoethyl-group, deacetylation and saponification of the reaction product tris(tetramethylammonium)-[S-(beta-D-glucuronate)-thio] undecahydro-closo-dodecaborate(3-) could be prepared. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：2780 / 2782

页数：3

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