Antiviral and Antioxidant Properties of Echinochrome A

被引：57

作者：

Fedoreyev, Sergey A. ^{[1
]}

Krylova, Natalia V. ^{[2
]}

Mishchenko, Natalia P. ^{[1
]}

Vasileva, Elena A. ^{[1
]}

Pislyagin, Evgeny A. ^{[1
]}

Iunikhina, Olga V. ^{[2
]}

Lavrov, Vyacheslav F. ^{[3
]}

Svitich, Oksana A. ^{[3
]}

Ebralidze, Linna K. ^{[3
]}

Leonova, Galina N. ^{[2
]}

机构：

[1] RAS, GB Elyakov Pacific Inst Bioorgan Chem, FEB, Vladivostok 690022, Russia

[2] RAS, GP Somov Inst Epidemiol & Microbiol, FEB, Vladivostok 690087, Russia

[3] II Mechnikov Res Inst Vaccines & Sera, Moscow 105064, Russia

来源：

MARINE DRUGS | 2018年 / 16卷 / 12期

关键词：

echinochrome A; composition of antioxidants; antioxidant activity; antiviral activity; OXIDATIVE STRESS; VITAMIN-E; FAR-EAST; INFECTION; MARINE;

D O I：

10.3390/md16120509

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The aim of this study was to examine the in vitro antioxidant and antiviral activities of echinochrome A and echinochrome-based antioxidant composition against tick-borne encephalitis virus (TBEV) and herpes simplex virus type 1 (HSV-1). The antioxidant composition, which is a mixture of echinochrome A, ascorbic acid, and -tocopherol (5:5:1), showed higher antioxidant and antiviral effects than echinochrome A. We suppose that echinochrome A and its composition can both directly affect virus particles and indirectly enhance antioxidant defense mechanisms in the hosting cell. The obtained results allow considering the echinochrome A and the composition of antioxidants on its basis as the promising agents with the both antioxidant and antiviral activities.

引用

下载

页数：10

共 50 条

[31] Cryopreservation of Crassostrea gigas oocytes, embryos and larvae using antioxidant echinochrome A and antifreeze protein AFP1
Naidenko, T
CRYO-LETTERS, 1997, 18 (06) : 375 - 382
[32] Synthesis of Glucoconjugates of Echinochrome Derivatives
Pokhilo, N. D.
Atopkina, L. N.
Utkina, N. K.
CHEMISTRY OF NATURAL COMPOUNDS, 2020, 56 (06) : 1122 - 1124
[33] The Possible Hypoglycemic Mechanisms of Echinochrome
Mohamed, Ayman Saber
Soliman, Amel Mahmoud
Marie, Mohamed-Assem Said
CURRENT DIABETES REVIEWS, 2018, 14 (04) : 334 - 338
[34] Antiviral and Antibacterial Effect of Honey Enriched with Rubus spp. as a Functional Food with Enhanced Antioxidant Properties
Grabek-Lejko, Dorota
Milek, Michal
Sidor, Ewelina
Puchalski, Czeslaw
Dzugan, Malgorzata
MOLECULES, 2022, 27 (15):
[35] Synthesis of Glucoconjugates of Echinochrome Derivatives
N. D. Pokhilo
L. N. Atopkina
N. K. Utkina
Chemistry of Natural Compounds, 2020, 56 : 1122 - 1124
[36] ANTIVIRAL PROPERTIES OF PHOTOSENSITIZERS
HUDSON, JB
TOWERS, GHN
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1988, 48 (03) : 289 - 296
[37] ANTIVIRAL PROPERTIES OF ADAMANTAMINE
CHERNUKH, AM
TOLMACHE.NS
RUDAKOVA, IS
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE,USSR, 1968, 65 (03): : 319 - &
[38] ANTIVIRAL PROPERTIES OF FUSIDIN
GONCHARS.TY
NAVASHIN, SM
ANTIBIOTIKI, 1971, 16 (01): : 57 - +
[39] Antiviral properties of clinoptilolite
Grce, M
Pavelic, K
MICROPOROUS AND MESOPOROUS MATERIALS, 2005, 79 (1-3) : 165 - 169
[40] 7-Ethyl-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone (echinochrome A): a DFT study of the antioxidant mechanism 2.* The structure of monosodium salts of echinochrome A and their reactions with the hydroperoxyl radical
Glazunov, V. P.
Berdyshev, D. V.
Novikov, V. L.
RUSSIAN CHEMICAL BULLETIN, 2010, 59 (01) : 43 - 54

← 1 2 3 4 5 →