Complex genetic and environmental relationships between psychological distress, fatigue and immune functioning: a twin study

被引:42
|
作者
Hickie, I
Bennett, B
Lloyd, A
Heath, A
Martin, N
机构
[1] Univ New S Wales, St George Hosp & Community Hlth Serv, Acad Dept Psychiat, Sch Psychiat, Sydney, NSW, Australia
[2] Univ New S Wales, St George Hosp & Community Hlth Serv, Acad Dept Psychiat, Inflammat Res Unit, Sydney, NSW, Australia
[3] Queensland Inst Med Res, Brisbane, Qld 4006, Australia
[4] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
关键词
D O I
10.1017/S0033291798007922
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Background. Although there is considerable support for adverse relationships between states of psychological and somatic distress and immune response, there is little evidence in humans of the relative contribution of genetic and environmental factors. Methods. This study utilized a twin methodology to examine the interplay between psychological distress, fatigue and immune function. We recorded a number of measures of distress, including conventional depression and anxiety as well as the somatic symptom of prolonged fatigue, and immune responsiveness (by delayed-type hypersensitivity skin response) in 124 normal adult twin pairs (79 monozygotic, 45 dizygotic). Results. While there were strong genetic influences on the psychological distress and fatigue factors (only some of which are common to both), familial aggregation of immune responsiveness arose mainly from environmental factors shared by both members of a twin pair. Phenotypic correlations between psychological and immune measures were negligible, but multivariate genetic modelling revealed that these masked larger genetic and environmental correlations of opposite sign. Negative environmental effects of psychological distress and fatigue on immune responsiveness were countered by a positive genetic relationship between psychological distress and immune function. Conclusions. Our study suggests that current psychoneuroimmunological hypotheses in humans need to be modified to place increasing importance on the individual's genotype. In this cohort immune responsiveness varied in response to a complex interplay of genetic and environmental factors. Additionally, although psychological distress and fatigue had some shared genetic determinants, independent genetic and environmental risk factors for fatigue were also identified.
引用
收藏
页码:269 / 277
页数:9
相关论文
共 50 条
  • [31] Genetic and environmental contributions to the relationship between education and anxiety disorders - a twin study
    Tambs, K.
    Kendler, K. S.
    Reichborn-Kjennerud, T.
    Aggen, S. H.
    Harris, J. R.
    Neale, M. C.
    Hettema, J. M.
    Sundet, J. M.
    Battaglia, M.
    Roysamb, E.
    ACTA PSYCHIATRICA SCANDINAVICA, 2012, 125 (03) : 203 - 212
  • [32] Genetic and Environmental Relationships of Metabolic and Weight Phenotypes to Metabolic Syndrome and Diabetes: The Healthy Twin Study
    Song, Yun-Mi
    Sung, Joohon
    Lee, Kayoung
    METABOLIC SYNDROME AND RELATED DISORDERS, 2015, 13 (01) : 36 - 44
  • [33] Genetic and environmental influences on psychological functioning in new cohorts of eldery people
    Pedersen, N
    INTERNATIONAL JOURNAL OF PSYCHOLOGY, 2000, 35 (3-4) : 90 - 91
  • [34] Giving distress tolerance the gift of context: An examination of daily situational factors and quadratic relationships in distress tolerance and psychological functioning
    Stiksma, Melissa C.
    Kashdan, Todd B.
    INTERNATIONAL JOURNAL OF PSYCHOLOGY, 2016, 51 : 638 - 638
  • [35] Sleep quality and psychological distress: a sex-limitation twin study
    Madrid-Valero, J. J.
    Kirkpatrick, R. M.
    Gonzalez-Javier, F.
    Gregory, A. M.
    Ordonana, J. R.
    BEHAVIOR GENETICS, 2020, 50 (06) : 465 - 465
  • [36] Effect of meditation on psychological distress and brain functioning: A randomized controlled study
    Travis, Fred
    Valosek, Laurent
    Konrad, Arthur
    Link, Janice
    Salerno, John
    Scheller, Ray
    Nidich, Sanford
    BRAIN AND COGNITION, 2018, 125 : 100 - 105
  • [37] Genetic and environmental relationships between head circumference growth in the first year of life and sociocognitive development in the second year: a longitudinal twin study
    Fujisawa, Keiko K.
    Ozaki, Koken
    Suzuki, Kunitake
    Yamagata, Shinji
    Kawahashi, Ikko
    Ando, Juko
    DEVELOPMENTAL SCIENCE, 2012, 15 (01) : 99 - 112
  • [38] The longitudinal association between marital and psychological functioning in socioeconomically disadvantaged relationships
    Kanter, Jeremy B.
    Proulx, Christine M.
    JOURNAL OF SOCIAL AND PERSONAL RELATIONSHIPS, 2021, 38 (09) : 2465 - 2473
  • [39] Relationships Between Psychological Distress and Affective, Behavioral, and Cognitive Experiences of Stuttering
    Panzarino, Randy
    Vanryckeghem, Martine
    Bedwell, Jeffrey S.
    Wendt, Oliver
    AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY, 2024, 33 (01) : 262 - 278
  • [40] Genetic and environmental contribution to the overlap between ADHD and ASD dimensions in adults: a twin study
    Ghirardi, Laura
    Pettersson, Erik
    Lichtenstein, Paul
    Larsson, Henrik
    Kuja-Halkola, Ralf
    BEHAVIOR GENETICS, 2017, 47 (06) : 658 - 658