A New Triterpene From Uncaria macrophylla and Its Antitumor Activity

被引：11
|
作者：
Sun, Guangli [1 ,2 ,3 ]
Zhang, Xiaopo [1 ,2 ]
Xu, Xudong [1 ,2 ]
Yang, Junshan [1 ,2 ]
Zhong, Mingliang [1 ,2 ]
Yuan, Jingquan [1 ,2 ,4 ]
机构：
[1] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China
[2] Peking Union Med Coll, Beijing 100193, Peoples R China
[3] Hebei United Univ, Sch Pharm, Dept Pharm, Tangshan 063000, Hebei, Peoples R China
[4] Guangxi Inst Med Plant Dev, Nanning 530023, Guangxi, Peoples R China
来源：
MOLECULES | 2012年 / 17卷 / 02期
关键词：
Uncaria macrophylla; Rubiaceae; 3; beta; 6; 19 alpha-trihydroxy-12-oleanen-28-oic acid; antitumor activity; ALKALOIDS; BARK;
D O I：
10.3390/molecules17021883
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
On our ongoing investigation, a new oleanolic triterpene, 3 beta, 6 beta, 19 alpha-trihydroxy-12-oleanen-28-oic acid (1) was obtained from the chloroform-soluble portion of the 90% alcohol-water extract of the stem bark of Uncaria macrophylla. Its structure was elucidated by extensive spectroscopic methods, including 1D and 2D (H-1-H-1 COSY, HSQC and HMBC) NMR and HR-ESI-MS. The cytotoxicities of the compound was evaluated against two cancer cell lines of MCF-7 and HepG2 by the MTT method, and the compound exhibited weak activities with the IC50 values of 78.2 mu g/mL and 73.9 mu g/mL.
引用
收藏
页码：1883 / 1889
页数：7
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