A julolidine-fused coumarin-NBD dyad for highly selective and sensitive detection of H2S in biological samples

被引：33

作者：

Ismail, Ismail ^{[1
]}

Wang, Dawei ^{[1
]}

Wang, Zhenghua ^{[1
]}

Wang, Dan ^{[1
]}

Zhang, Changyu ^{[2
]}

Yi, Long ^{[2
,3
]}

Xi, Zhen ^{[1
,3
]}

机构：

[1] Nankai Univ, State Key Lab Elementoorgan Chem, Natl Pesticide Engn Res Ctr, Dept Chem Biol,Coll Chem, Tianjin 300071, Peoples R China

[2] Beijing Univ Chem Technol, Beijing Key Lab Bioproc, 15 Beisanhuan East Rd, Beijing 100029, Peoples R China

[3] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin, Peoples R China

来源：

DYES AND PIGMENTS | 2019年 / 163卷

基金：

国家重点研发计划;

关键词：

Julolidine-fused coumarin-NBD probe; H2S detection; Cell imaging; Zebrafish imaging; RATIOMETRIC FLUORESCENT-PROBE; TURN-ON PROBE; HYDROGEN-SULFIDE; RAPID DETECTION; LIVING CELLS; CYSTEINE; THIOLYSIS; CANCER; AUTOPHAGY; SYNTHASE;

D O I：

10.1016/j.dyepig.2018.12.064

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new julolidine-fused coumarin-NBD probe 2 for H2S detection is rationally designed based on the DFT culations. This improved probe exhibits faster and larger off-on response as well as higher sensitivity compare with the previous coumarin-NBD probe 1. Moreover, 2 possesses excellent selectivity and good biocompatibility which can be employed to image H2S in living cells and in zebrafish.

引用

页码：700 / 706

页数：7

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