The crucial role of the CCL2/CCR2 axis in neointimal hyperplasia after arterial injury in hyperlipidemic mice involves early monocyte recruitment and CCL2 presentation on platelets

被引：0
|
作者：
Schober, A [1 ]
Zernecke, A [1 ]
Liehn, EA [1 ]
von Hundelshausen, P [1 ]
Knarren, S [1 ]
Kuziel, WA [1 ]
Weber, C [1 ]
机构：
[1] Univ Klinikum Aachen, Lehr & Forschungsgebiet Kardiovask Mol Biol, Aachen, Germany
来源：
Cardio-Visions 2004: JUNGE EXZELLENZE IN DER KARDIOVASKULAREN FORSCHUNG | 2005年
关键词：
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Our data define a novel function of JE/CCL2 as an arrest chemokine in early monocyte recruitment after endothelial denudation of arteries in hyperlipidemic mice, which appears to require its local concentration and presentation on adherent platelets. This may represent the principle mechanism accounting for reduced neointimal hyperplasia and macrophage content in CCR2-deficient apoE(-/-) mice.
引用
收藏
页码：27 / 28
页数：2
相关论文
共 50 条
  • [31] Crucial Involvement of the CCR2/CCL2 Interactions in Azoxymethane/Dextran Sodium Sulfate-induced Colon Carcinogenesis in Mice
    Popivanova B.K.
    Kostadinova F.I.
    Mukaida N.
    Inflammation Research, 2009, 58 (Suppl 2) : S229 - S233
  • [32] The role of CCL2 CCL17 CCL22-CCR4 axis in prostate cancer metastasis
    Maolake, Aerken
    Izumi, Kouji
    Natsagdorji, Ariunbold
    Iwamoto, Hiroaki
    Mizokami, Atsushi
    CANCER RESEARCH, 2016, 76
  • [33] Impact of CCL2 and CCR2 chemokine/receptor deficiencies on macrophage recruitment and continuous glucose monitoring in vivo
    Klueh, Ulrike
    Czajkowski, Caroline
    Ludzinska, Izabela
    Qiao, Yi
    Frailey, Jackman
    Kreutzer, Donald L.
    BIOSENSORS & BIOELECTRONICS, 2016, 86 : 262 - 269
  • [34] The CCL2/CCR2 Axis in the Pathogenesis of HIV-1 Infection: A New Cellular Target for Therapy?
    Covino, Daniela Angela
    Sabbatucci, Michela
    Fantuzzi, Laura
    CURRENT DRUG TARGETS, 2016, 17 (01) : 76 - 110
  • [35] The CCL2/CCR2 Axis Affects Transmigration and Proliferation but Not Resistance to Chemotherapy of Acute Myeloid Leukemia Cells
    Macanas-Pirard, Patricia
    Quezada, Thomas
    Navarrete, Leonardo
    Broekhuizen, Richard
    Leisewitz, Andrea
    Nervi, Bruno
    Ramirez, Pablo A.
    PLOS ONE, 2017, 12 (01):
  • [36] ROLE OF NEURONAL CCL2/CCR2 IN ALCOHOL WITHDRAWAL INDUCED ANXIETY-LIKE BEHAVIOR
    Harper, K. M.
    Knapp, D. J.
    Todd, C. A.
    Aurelian, L.
    Breese, G. R.
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2018, 42 : 25A - 25A
  • [37] Exploration of the mechanism of Taohong Siwu Decoction for the treatment of ischemic stroke based on CCL2/CCR2 axis
    Li, Jingjing
    Zhang, Lijuan
    Xue, Sujun
    Yu, Chao
    Li, Yumeng
    Li, Shuangping
    Ye, Qingping
    Duan, Xianchun
    Peng, Daiyin
    FRONTIERS IN PHARMACOLOGY, 2024, 15
  • [38] Mechanistic insights into the role of the chemokine CCL2/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity
    Dansereau, Marc-Andre
    Midavaine, Elora
    Begin-Lavallee, Valerie
    Belkouch, Mounir
    Beaudet, Nicolas
    Longpre, Jean-Michel
    Melik-Parsadaniantz, Stephane
    Sarret, Philippe
    JOURNAL OF NEUROINFLAMMATION, 2021, 18 (01)
  • [39] The CCL2/CCR2 Axis in Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome Following Lung Transplantation
    Hovanessian, A. Der
    Palchevskiy, V.
    Weigt, S. S.
    Shino, M. Y.
    Gregson, A. L.
    Kubak, B. M.
    Lynch, J. P.
    Saggar, R.
    Ross, D. J.
    Ardehali, A.
    Elashoff, R. M.
    Belperio, J. A.
    JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2013, 32 (04): : S28 - S29
  • [40] Harmonizing hope: navigating the osteoarthritis melody through the CCL2/CCR2 axis for innovative therapeutic avenues
    Abbasifard, Mitra
    Khorramdelazad, Hossein
    FRONTIERS IN IMMUNOLOGY, 2024, 15
12345