The crucial role of the CCL2/CCR2 axis in neointimal hyperplasia after arterial injury in hyperlipidemic mice involves early monocyte recruitment and CCL2 presentation on platelets

被引：0
|
作者：
Schober, A [1 ]
Zernecke, A [1 ]
Liehn, EA [1 ]
von Hundelshausen, P [1 ]
Knarren, S [1 ]
Kuziel, WA [1 ]
Weber, C [1 ]
机构：
[1] Univ Klinikum Aachen, Lehr & Forschungsgebiet Kardiovask Mol Biol, Aachen, Germany
来源：
Cardio-Visions 2004: JUNGE EXZELLENZE IN DER KARDIOVASKULAREN FORSCHUNG | 2005年
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D O I：
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中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Our data define a novel function of JE/CCL2 as an arrest chemokine in early monocyte recruitment after endothelial denudation of arteries in hyperlipidemic mice, which appears to require its local concentration and presentation on adherent platelets. This may represent the principle mechanism accounting for reduced neointimal hyperplasia and macrophage content in CCR2-deficient apoE(-/-) mice.
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页码：27 / 28
页数：2
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