Japonicones A-C: Three lindenane sesquiterpenoid dimers with a 12-membered ring core from Chloranthus japonicus

被引：24

作者：

Yan, Huan ^{[1
,2
]}

Qin, Xu-Jie ^{[1
,2
]}

Li, Xu-Hong ^{[1
,2
]}

Yu, Qian ^{[3
]}

Ni, Wei ^{[1
,2
]}

He, Li ^{[4
]}

Liu, Hai-Yang ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[2] Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China

[3] Sun Yat Sen Univ, Sch Pharmaceut Sci, Inst Med Chem & Chem Biol, Guangzhou 510006, Guangdong, Peoples R China

[4] Kunming Med Univ, Affiliated Hosp 1, Dept Dermatol, Kunming 650032, Yunnan, Peoples R China

来源：

TETRAHEDRON LETTERS | 2019年 / 60卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Chloranthus japonicus; Lindenane sesquiterpenoid dimer; Japonicones A-C; ECD calculation; CHEMICAL-CONSTITUENTS; PLANTS;

D O I：

10.1016/j.tetlet.2019.01.040

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Japonicones A-C (1-3), three new dimeric lindenane-type sesquiterpenoids featuring a rare 12-membered ring framework, were isolated from the whole plants of Chloranthus japonicus Sieb. Their structures and absolute configurations were unequivocally established by a combination of spectroscopic data, ECD calculation, and X-ray crystallography. Compounds 1-3 were evaluated for their DNA Topoisomerase I (Top1) inhibitory, cytotoxic, and antibacterial activities. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：713 / 717

页数：5