Japonicones A-C: Three lindenane sesquiterpenoid dimers with a 12-membered ring core from Chloranthus japonicus

被引：24
|
作者：
Yan, Huan [1 ,2 ]
Qin, Xu-Jie [1 ,2 ]
Li, Xu-Hong [1 ,2 ]
Yu, Qian [3 ]
Ni, Wei [1 ,2 ]
He, Li [4 ]
Liu, Hai-Yang [1 ,2 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
[2] Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
[3] Sun Yat Sen Univ, Sch Pharmaceut Sci, Inst Med Chem & Chem Biol, Guangzhou 510006, Guangdong, Peoples R China
[4] Kunming Med Univ, Affiliated Hosp 1, Dept Dermatol, Kunming 650032, Yunnan, Peoples R China
来源：
TETRAHEDRON LETTERS | 2019年 / 60卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Chloranthus japonicus; Lindenane sesquiterpenoid dimer; Japonicones A-C; ECD calculation; CHEMICAL-CONSTITUENTS; PLANTS;
D O I：
10.1016/j.tetlet.2019.01.040
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Japonicones A-C (1-3), three new dimeric lindenane-type sesquiterpenoids featuring a rare 12-membered ring framework, were isolated from the whole plants of Chloranthus japonicus Sieb. Their structures and absolute configurations were unequivocally established by a combination of spectroscopic data, ECD calculation, and X-ray crystallography. Compounds 1-3 were evaluated for their DNA Topoisomerase I (Top1) inhibitory, cytotoxic, and antibacterial activities. (C) 2019 Elsevier Ltd. All rights reserved.
引用
收藏
页码：713 / 717
页数：5
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