Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant

被引：182
|
作者：
Sridhar, Siddharth [1 ]
Yip, Cyril C. Y. [1 ]
Wu, Shusheng [1 ]
Cai, Jianpiao [1 ]
Zhang, Anna Jin-Xia [1 ]
Leung, Kit-Hang [1 ]
Chung, Tom W. H. [1 ]
Chan, Jasper F. W. [1 ,2 ]
Chan, Wan-Mui [1 ]
Teng, Jade L. L. [1 ]
Au-Yeung, Rex K. H. [1 ]
Cheng, Vincent C. C. [1 ]
Chen, Honglin [1 ]
Lau, Susanna K. P. [1 ]
Woo, Patrick C. Y. [1 ]
Xia, Ning-Shao [3 ]
Lo, Chung-Mau [1 ,2 ]
Yuen, Kwok-Yung [1 ,2 ]
机构：
[1] Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China
[2] Univ Hong Kong Shenzhen Hosp, Shenzhen, Peoples R China
[3] Xiamen Univ, Xiamen, Peoples R China
来源：
EMERGING INFECTIOUS DISEASES | 2018年 / 24卷 / 12期
关键词：
TRANSMISSION; INFECTION; RELEASE; HEV;
D O I：
10.3201/eid2412.180937
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
All hepatitis E virus (HEV) variants reported to infect humans belong to the species Orthohepevirus A (HEV-A). The zoonotic potential of the species Orthohepevirus C (HEV-C), which circulates in rats and is highly divergent from HEV-A, is unknown. We report a liver transplant recipient with hepatitis caused by HEV-C infection. We detected HEV-C RNA in multiple clinical samples and HEV-C antigen in the liver. The complete genome of the HEV-C isolate had 93.7% nt similarity to an HEV-C strain from Vietnam. The patient had preexisting HEV antibodies, which were not protective against HEV-C infection. Ribavirin was an effective treatment, resulting in resolution of hepatitis and clearance of HEV-C viremia. Testing for this zoonotic virus should be performed for immunocompromised and immunocompetent patients with unexplained hepatitis because routine hepatitis E diagnostic tests may miss HEV-C infection. HEV-C is also a potential threat to the blood product supply.
引用
收藏
页码：2241 / 2250
页数：10
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