CTCF binds to sites in the major histocompatibility complex that are rapidly reconfigured in response to interferon-gamma

被引：11

作者：

Ottaviani, Diego ^{[1
]}

Lever, Elliott ^{[1
,2
]}

Mao, Shihong ^{[3
,4
]}

Christova, Rossitza ^{[1
]}

Ogunkolade, Babatunji W. ^{[1
]}

Jones, Tania A. ^{[1
]}

Szary, Jaroslaw ^{[1
]}

Aarum, Johan ^{[1
]}

Mumin, Muhammad A. ^{[1
]}

Pieri, Christopher A. ^{[1
]}

Krawetz, Stephen A. ^{[3
,4
]}

Sheer, Denise ^{[1
]}

机构：

[1] Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London E1 2AT, England

[2] UCL, Sch Med, London W1N 8AA, England

[3] Wayne State Univ, Sch Med, Ctr Mol Med & Genet, CS Mott Ctr, Detroit, MI 48201 USA

[4] Wayne State Univ, Sch Med, Dept Obstet & Gynecol, CS Mott Ctr, Detroit, MI 48201 USA

来源：

NUCLEIC ACIDS RESEARCH | 2012年 / 40卷 / 12期

关键词：

II GENE-EXPRESSION; IN-SILICO; CHROMATIN; MHC; INSULATOR; TRANSCRIPTION; ORGANIZATION; ARCHITECTURE; ASSOCIATION; REGIONS;

D O I：

10.1093/nar/gks158

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Activation of the major histocompatibility complex (MHC) by interferon-gamma (IFN-gamma) is a fundamental step in the adaptive immune response to pathogens. Here, we show that reorganization of chromatin loop domains in the MHC is evident within the first 30 min of IFN-gamma treatment of fibroblasts, and that further dynamic alterations occur up to 6 h. These very rapid changes occur at genomic sites which are occupied by CTCF and are close to IFN-gamma-inducible MHC genes. Early responses to IFN-gamma are thus initiated independently of CIITA, the master regulator of MHC class II genes and prepare the MHC for subsequent induction of transcription.

引用

页码：5262 / 5270

页数：9

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