CTCF binds to sites in the major histocompatibility complex that are rapidly reconfigured in response to interferon-gamma

被引：11
|
作者：
Ottaviani, Diego [1 ]
Lever, Elliott [1 ,2 ]
Mao, Shihong [3 ,4 ]
Christova, Rossitza [1 ]
Ogunkolade, Babatunji W. [1 ]
Jones, Tania A. [1 ]
Szary, Jaroslaw [1 ]
Aarum, Johan [1 ]
Mumin, Muhammad A. [1 ]
Pieri, Christopher A. [1 ]
Krawetz, Stephen A. [3 ,4 ]
Sheer, Denise [1 ]
机构：
[1] Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London E1 2AT, England
[2] UCL, Sch Med, London W1N 8AA, England
[3] Wayne State Univ, Sch Med, Ctr Mol Med & Genet, CS Mott Ctr, Detroit, MI 48201 USA
[4] Wayne State Univ, Sch Med, Dept Obstet & Gynecol, CS Mott Ctr, Detroit, MI 48201 USA
来源：
NUCLEIC ACIDS RESEARCH | 2012年 / 40卷 / 12期
关键词：
II GENE-EXPRESSION; IN-SILICO; CHROMATIN; MHC; INSULATOR; TRANSCRIPTION; ORGANIZATION; ARCHITECTURE; ASSOCIATION; REGIONS;
D O I：
10.1093/nar/gks158
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Activation of the major histocompatibility complex (MHC) by interferon-gamma (IFN-gamma) is a fundamental step in the adaptive immune response to pathogens. Here, we show that reorganization of chromatin loop domains in the MHC is evident within the first 30 min of IFN-gamma treatment of fibroblasts, and that further dynamic alterations occur up to 6 h. These very rapid changes occur at genomic sites which are occupied by CTCF and are close to IFN-gamma-inducible MHC genes. Early responses to IFN-gamma are thus initiated independently of CIITA, the master regulator of MHC class II genes and prepare the MHC for subsequent induction of transcription.
引用
收藏
页码：5262 / 5270
页数：9
相关论文
共 50 条
12345