Evidence for conserved DNA and histone H3 methylation reprogramming in mouse, bovine and rabbit zygotes

被引：62

作者：

Lepikhov, Konstantin ^{[1
]}

Zakhartchenko, Valeri ^{[2
]}

Hao, Ru ^{[2
]}

Yang, Feikun ^{[2
]}

Wrenzycki, Christine ^{[3
]}

Niemann, Heiner ^{[4
]}

Wolf, Eckhard ^{[2
]}

Walter, Joern ^{[1
]}

机构：

[1] Univ Saarland, Nat Sci Tech Fac 3, D-66123 Saarbrucken, Germany

[2] Univ Munich, Dept Mol Anim Breeding & Biotechnol, D-81377 Munich, Germany

[3] Univ Vet Med, Clin Cattle, Reprod Med Unit, D-30173 Hannover, Germany

[4] Inst Anim Breeding FAL, Dept Biotechnol, D-31535 Neustadt, Germany

来源：

EPIGENETICS & CHROMATIN | 2008年 / 1卷 / 1期

关键词：

D O I：

10.1186/1756-8935-1-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: In mammals the parental genomes are epigenetically reprogrammed after fertilization. This reprogramming includes a rapid demethylation of the paternal (sperm-derived) chromosomes prior to DNA replication in zygotes. Such active DNA demethylation in the zygote has been documented for several mammalian species, including mouse, rat, pig, human and cow, but questioned to occur in rabbit. Results: When comparing immunohistochemical patterns of antibodies against 5-methyl-cytosine, H3K4me3 and H3K9me2 modifications we observe similar pronuclear distribution and dynamics in mouse, bovine and rabbit zygotes. In rabbit DNA demethylation of the paternal chromosomes occurs at slightly advanced pronuclear stages. We also show that the rabbit oocyte rapidly demethylates DNA of donor fibroblast after nuclear transfer. Conclusion: Our data reveal that major events of epigenetic reprogramming during pronuclear maturation, including mechanisms of active DNA demethylation, are apparently conserved among mammalian species.

引用

页数：11

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