Nitric oxide synthase inhibition delays low-frequency stimulation-induced satellite cell activation in rat fast-twitch muscle

被引：0

作者：

Martins, Karen J. B. ^{[1
]}

MacLean, Ian ^{[1
]}

Murdoch, Gordon K. ^{[4
]}

Dixon, Walter T. ^{[5
]}

Putman, Charles T. ^{[1
,2
,3
]}

机构：

[1] Univ Alberta, Exercise Biochem Lab, Fac Phys Educ & Recreat, Edmonton, AB T6G 2H9, Canada

[2] Univ Alberta, Fac Med & Dent, Ctr Neurosci, Edmonton, AB T6G 2H9, Canada

[3] Univ Alberta, Van Vliet Ctr E 417, Edmonton, AB T6G 2H9, Canada

[4] Univ Idaho, Anim & Vet Sci Dept, Moscow, ID 83844 USA

[5] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2H9, Canada

来源：

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM | 2011年 / 36卷 / 06期

基金：

加拿大自然科学与工程研究理事会;

关键词：

nitric oxide; L-NAME; chronic low-frequency stimulation; BrdU; HGF; STRETCH-INDUCED ACTIVATION; SKELETAL-MUSCLE; HYPERTROPHY; ABLATION;

D O I：

10.1139/H11-091

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

This study examined the effect of nitric oxide synthase (NOS) inhibition via N-omega-nitro-L-arginine methyl ester (L-NAME) administration on low-frequency stimulation-induced satellite cell (SC) activation in rat skeletal muscle. L-NAME only delayed stimulation-induced increases in SC activity. Also, stimulation-induced increases in hepatocyte growth factor (HGF) mRNA and protein expression were only abrogated at the mRNA level in L-NAME-treated animals. Therefore, early stimulation-induced SC activation appears to be NOS-dependent, while continued activation may involve NOS-independent HGF translational control mechanisms.

引用

页码：996 / 1000

页数：5

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