Copper-Catalyzed Asymmetric 1,4-Addition of Alkenyl Alanes to N-Substituted-2-3-dehydro-4-piperidones

被引：43
|
作者：
Mueller, Daniel [1 ]
Alexakis, Alexandre [1 ]
机构：
[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 07期
基金：
新加坡国家研究基金会;
关键词：
ENANTIOSELECTIVE CONJUGATE ADDITION; TRIALKYLALUMINUM REAGENTS; TRISUBSTITUTED ENONES; ARYLBORONIC ACIDS; CONSTRUCTION; ARYL; HYDROALUMINATION; LIGANDS; ALKYNES;
D O I：
10.1021/ol3004436
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Readily available vinyl alanes are used in the Cu-catalyzed asymmetric conjugate addition reaction to N-substituted-2-3-dehydro-4-piperidones. The enhanced reactivity of recently developed and easily prepared phosphine amine ligands in combination with inexpensive Cu(II)naphtenate (CuNp) allows the introduction of a great variety of alkenyl, alkyl, and aryl aluminums in high enantioselectivity.
引用
收藏
页码：1842 / 1845
页数：4
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