Tryptophan and quality of life in colorectal cancer

被引：0
|
作者：
Huang, A
Fuchs, D
Widner, B
Glover, C
Henderson, DC
Allen-Mersh, TG
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Chelsea & Westminster Hosp, Fac Med, Dept Surg, London SW10 9NH, England
[2] Univ London Imperial Coll Sci Technol & Med, Chelsea & Westminster Hosp, Fac Med, Dept Immunol, London SW10 9NH, England
[3] Univ Innsbruck, Ludwig Boltzmann Inst AIDS Res, A-6020 Innsbruck, Austria
[4] Univ Innsbruck, Inst Med Biochem & Chem, A-6020 Innsbruck, Austria
来源：
DEVELOPMENTS IN TRYPTOPHAN AND SEROTONIN METABOLISM | 2003年 / 527卷
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We tested the hypothesis that reduced tryptophan availability due to immunological stimulation in colorectal cancer impairs quality of life (QoL) by measuring serum tryptophan levels, and correlating them with serum immunological markers and with QoL indices. Serum tryptophan level was significantly reduced in cancer patients compared with healthy controls. Serum tryptophan/kynurenine ratio and neopterin level were significantly increased in cancer, with a significant correlation between the two variables. Reduced serum tryptophan correlated significantly with worse QoL scores. The results support the hypothesis that in colorectal cancer, QoL impairment may be due to serum tryptophan depletion mediated by immunological activation.
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页码：353 / 358
页数：6
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