Syntheses, crystal structures, and Jack bean urease inhibitory activities of copper(II) complexes derived from 4-tert-butyl-N′-(1-(pyridin-2-yl)ethylidene)benzohydrazide

被引：7
|
作者：
Guo, Sihan [1 ]
Wang, Tianrui [2 ]
Xin, Jiajin [2 ]
Hu, Qiqige [1 ]
Ren, Shanfa [2 ]
Sheng, Guihua [2 ]
Pan, Lin [1 ]
Zhang, Chenglu [1 ]
Li, Kun [1 ]
You, Zhonglu [1 ]
机构：
[1] Liaoning Normal Univ, Dept Chem & Chem Engn, Dalian, Peoples R China
[2] Shandong Univ Technol, Sch Life Sci, Zibo, Peoples R China
来源：
JOURNAL OF COORDINATION CHEMISTRY | 2017年 / 70卷 / 20期
关键词：
Hydrazone; copper complex; crystal structure; urease inhibition; molecular docking; HELICOBACTER-PYLORI UREASE; HYDRAZONE COMPLEXES; METAL-IONS; CHEMISTRY; MECHANISM; LIGANDS; BINDING;
D O I：
10.1080/00958972.2017.1390569
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Two new copper(II) complexes, [CuL(HL)]center dot ClO4 (1) and [Cu2Br2L2]center dot 0.85H(2)O (2), where L is the monoanionic form of 4-tert-butyl-N'-(1-(pyridin-2-yl) ethylidene) benzohydrazide (HL), have been prepared. The complexes were characterized by infrared and UV-vis spectra, and single crystal X-ray diffraction. Complex 1 is a mononuclear copper(II) species and 2 is a bromido-bridged dinuclear copper(II) species. The Cu ion in 1 is in an octahedral coordination mode and that in 2 is trigonal-bipyramidal. The Jack bean urease inhibitory assay indicated that 2 is active, with IC50 value of 20.6 +/- 2.3 mu mol L-1, while 1 is inactive. Molecular docking of 2 with Jack bean urease was studied. [GRAPHICS] .
引用
收藏
页码：3449 / 3458
页数：10
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