Discordance between antibody and T cell responses in recipients of trivalent inactivated influenza vaccine

被引：30
|
作者：
Co, Mary Dawn T. [1 ]
Orphin, Laura [1 ]
Cruz, John [1 ]
Pazoles, Pamela [1 ]
Rothman, Alan L. [1 ]
Ennis, Francis A. [1 ]
Terajima, Masanori [1 ]
机构：
[1] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vacine Res, Worcester, MA 01655 USA
来源：
VACCINE | 2008年 / 26卷 / 16期
关键词：
B cells; T cells; influenza;
D O I：
10.1016/j.vaccine.2008.02.024
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Thirty adults were tested for humoral and cellular immune responses following immunization with the trivalent inactivated influenza vaccine. Modest but significant inverse correlations between the baseline and the fold changes in the number of IFN-gamma-producing cells and the levels of neutralizing antibodies were observed. Specific increases in proliferative responses in the CD8 CD45RA+ population were noted after vaccination. Minimal correlations between neutralizing antibody titers and the number of IFN gamma-producing cells in terms of prevaccination levels or fold increases were observed. These results show specific increases in a CD8 T cell subset and discordant T and B responses induced by the trivalent inactivated influenza vaccine. (c) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1990 / 1998
页数：9
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