Molecular-genetic mechanisms of cornea morphogenesis

被引：0
|
作者：
Panova, I. G. [1 ]
Markitantova, Yu V. [1 ]
Smirnova, Yu A. [1 ]
Zinovieva, R. D. [1 ]
机构：
[1] Russian Acad Sci, Koltzov Inst Dev Biol, Moscow 119334, Russia
来源：
BIOLOGY BULLETIN | 2015年 / 42卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
HOMEOBOX GENE; STEM-CELLS; TGF-BETA; TRANSCRIPTION FACTORS; EPITHELIAL-CELLS; PAX6; EXPRESSION; RIEGER-SYNDROME; MESSENGER-RNA; NEURAL CREST; PITX2;
D O I：
10.1134/S1062359015020077
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In this paper, we analyzed our own results and published data on the expression of regulatory genes encoding transcription factors Pax6/PAX6, Pitx2/PITX2, Fox1/FOXC1, Prox1/PROX1, Oct4/OCT4, Nanog/NANOG, and TGF beta 2 signaling protein during morphogenesis of the cornea in vertebrates. We considered the results obtained for the cornea of model animals, primarily mice, and human fetal cornea. The main possibility of establishing common mechanisms of eye development in vertebrates in health and disease is comparative studies of eye morphogenesis of humans and animal models.
引用
收藏
页码：83 / 91
页数：9
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