The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26

被引:49
|
作者
Koehler, MR
Wissinger, B
Gorboulev, V
Koepsell, H
Schmid, M
机构
[1] Univ Wurzburg, Inst Anat, Dept Anat, D-97070 Wurzburg, Germany
[2] Univ Wurzburg, Biozentrum, Dept Human Genet, Wurzburg, Germany
[3] Univ Tubingen, Hosp Eye, Genet Mol Lab, Tubingen, Germany
来源
CYTOGENETICS AND CELL GENETICS | 1997年 / 79卷 / 3-4期
关键词
D O I
10.1159/000134720
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Polyspecific transporters for organic cations (OCT) belong to a new protein family which also include organic anion transporters. The first human transporters from this family (OCT1, OCT2) have been recently cloned. They translocate small cations like tetraethylammonium, choline and monoamine neurotransmitters and are involved in hepatic and renal cation excretion, respectively. We have localized the OCT1 and OCT2 genes (SLC22A1, SLC22A2) on chromosome 6q26.
引用
收藏
页码:198 / 200
页数:3
相关论文
共 50 条
  • [31] Organic Cation Transporter OCTs (SLC22) and MATEs (SLC47) in the Human Kidney
    Hideyuki Motohashi
    Ken-ichi Inui
    [J]. The AAPS Journal, 2013, 15 : 581 - 588
  • [32] Effects of genetic variants in SLC22A2 organic cation transporter 2 and SLC47A1 multidrug and toxin extrusion 1 transporter on cisplatin-induced adverse events
    Iwata, Kazufumi
    Aizawa, Keiji
    Kamitsu, Saori
    Jingami, Sachiko
    Fukunaga, Eiko
    Yoshida, Minoru
    Yoshimura, Misato
    Hamada, Akinobu
    Saito, Hideyuki
    [J]. CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2012, 16 (06) : 843 - 851
  • [33] Genetic polymorphisms and haplotypes of the organic cation transporter 1 gene (SLC22A1) in the Xhosa population of South Africa
    Jacobs, Clifford
    Pearce, Brendon
    Du Plessis, Morne
    Hoosain, Nisreen
    Benjeddou, Mongi
    [J]. GENETICS AND MOLECULAR BIOLOGY, 2014, 37 (02) : 350 - 359
  • [34] Effects of genetic variants in SLC22A2 organic cation transporter 2 and SLC47A1 multidrug and toxin extrusion 1 transporter on cisplatin-induced adverse events
    Kazufumi Iwata
    Keiji Aizawa
    Saori Kamitsu
    Sachiko Jingami
    Eiko Fukunaga
    Minoru Yoshida
    Misato Yoshimura
    Akinobu Hamada
    Hideyuki Saito
    [J]. Clinical and Experimental Nephrology, 2012, 16 : 843 - 851
  • [35] Kidney-specific expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation
    Aoki, Masayo
    Terada, Tomohiro
    Kajiwara, Moto
    Ogasawara, Ken
    Ikai, Iwao
    Ogawa, Osamu
    Katsura, Toshiya
    Inui, Ken-ichi
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2008, 295 (01) : F165 - F170
  • [36] Expression of organic cation transporter SLC22A16 in human endometria
    Sato, Naoko
    Ito, Kiyoshi
    Onogawa, Toru
    Akahira, Jun-ichi
    Unno, Michiaki
    Abe, Takaaki
    Niikura, Hitoshi
    Yaegashi, Nobuo
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2007, 26 (01) : 53 - 60
  • [37] Expression and analysis of two novel rat organic cation transporter homologs, SLC22A17 and SLC22A23
    Katie M. Bennett
    Jun Liu
    Courtney Hoelting
    James Stoll
    [J]. Molecular and Cellular Biochemistry, 2011, 352 : 143 - 154
  • [38] PharmGKB update: I. Genetic variants of the organic cation transporter 2 (OCT2, SLC22A2)
    Leabman, MK
    Huang, CC
    Stryke, D
    Johns, SJ
    Kawamoto, M
    Ferrin, TE
    Deyoung, J
    Taylor, TR
    De La Cruz, M
    Herskowitz, I
    Giacomini, KM
    [J]. PHARMACOLOGICAL REVIEWS, 2003, 55 (03) : 399 - 399
  • [39] Expression and analysis of two novel rat organic cation transporter homologs, SLC22A17 and SLC22A23
    Bennett, Katie M.
    Liu, Jun
    Hoelting, Courtney
    Stoll, James
    [J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 2011, 352 (1-2) : 143 - 154
  • [40] Downregulation of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) in human hepatocellular carcinoma and their prognostic significance
    Heise, Michael
    Lautem, Anja
    Knapstein, Johanna
    Schattenberg, Joern M.
    Hoppe-Lotichius, Maria
    Foltys, Daniel
    Weiler, Nina
    Zimmermann, Anca
    Schad, Arno
    Gruendemann, Dirk
    Otto, Gerd
    Galle, Peter R.
    Schuchmann, Marcus
    Zimmermann, Tim
    [J]. BMC CANCER, 2012, 12