Is Long COVID a State of Systemic Pericyte Disarray?

被引：4
|
作者：
Jones, Olcay Y. [1 ]
Yeralan, Sencer [2 ]
机构：
[1] Walter Reed Natl Mil Med Ctr, Pediat Rheumatol, Bethesda, MD 20889 USA
[2] ADA Univ, Sch IT & Engn, AZ-1008 Baku, Azerbaijan
来源：
JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 03期
关键词：
Long COVID; pericyte; Triple-A; complex dynamical systems; entropy; emergent systems intelligence; MESENCHYMAL STEM-CELLS; BRAIN;
D O I：
10.3390/jcm11030572
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The most challenging aspect of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) or Long COVID remains for the discordance between the viral damage from acute infection in the recent past and susceptibility of Long COVID without clear evidence of post infectious inflammation or autoimmune reactions. In this communication we propose that disarray of pericytes plays a central role in emerge of Long COVID. We assume pericytes are agents with "Triple-A" qualities, i.e., analyze-adapt and advance, necessary for sustainability of host homeostasis. Based on this view, we further suggest Long COVID may provide a model system to integrate system theory and complex adaptive systems to explore a new class of maladies those are currently not well defined and with no remedies.
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页数：9
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