Is Long COVID a State of Systemic Pericyte Disarray?

被引：4

作者：

Jones, Olcay Y. ^{[1
]}

Yeralan, Sencer ^{[2
]}

机构：

[1] Walter Reed Natl Mil Med Ctr, Pediat Rheumatol, Bethesda, MD 20889 USA

[2] ADA Univ, Sch IT & Engn, AZ-1008 Baku, Azerbaijan

来源：

JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 03期

关键词：

Long COVID; pericyte; Triple-A; complex dynamical systems; entropy; emergent systems intelligence; MESENCHYMAL STEM-CELLS; BRAIN;

D O I：

10.3390/jcm11030572

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The most challenging aspect of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) or Long COVID remains for the discordance between the viral damage from acute infection in the recent past and susceptibility of Long COVID without clear evidence of post infectious inflammation or autoimmune reactions. In this communication we propose that disarray of pericytes plays a central role in emerge of Long COVID. We assume pericytes are agents with "Triple-A" qualities, i.e., analyze-adapt and advance, necessary for sustainability of host homeostasis. Based on this view, we further suggest Long COVID may provide a model system to integrate system theory and complex adaptive systems to explore a new class of maladies those are currently not well defined and with no remedies.

引用

页数：9

共 50 条

[1] STATE OF DISARRAY
JOCHNOWITZ, G
[J]. NEW REPUBLIC, 1991, 205 (02) : 6 - 6
[2] SYSTEMIC HYPERTENSION PRODUCES PERICYTE CHANGES IN RETINAL CAPILLARIES
WALLOW, IHL
BINDLEY, CD
REBOUSSIN, DM
GANGE, SJ
FISHER, MR
[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1993, 34 (02) : 420 - 430
[3] Long COVID: systemic inflammation and obesity as therapeutic targets
Florencio, Lidiane L.
Fernandez-de-las-Penas, Cesar
[J]. LANCET RESPIRATORY MEDICINE, 2022, 10 (08): : 726 - 727
[4] A STATE IN DISARRAY - CONDITIONS OF CHADS SURVIVAL - KELLEY,MP
BUIJTENHUIJS, R
[J]. CANADIAN JOURNAL OF AFRICAN STUDIES-REVUE CANADIENNE DES ETUDES AFRICAINES, 1987, 21 (02): : 292 - 294
[5] Pericyte Rho GTPase mediates both pericyte contractile phenotype and capillary endothelial growth state
Kutcher, Matthew E.
Kolyada, Alexey Y.
Surks, Howard K.
Herman, Ira M.
[J]. AMERICAN JOURNAL OF PATHOLOGY, 2007, 171 (02): : 693 - 701
[6] SYSTEMIC HYPERTENSION (HTN) PRODUCES PERICYTE CHANGES IN RETINAL CAPILLARIES
WALLOW, IHL
BINDLEY, C
REBOUSSIN, D
GANGE, S
FISHER
[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1992, 33 (04) : 804 - 804
[7] The Ethiopian Party-State in disarray, an interview with Rene Lefort
Planel, Sabine
Lefort, Rene
[J]. ESPACE POLITIQUE, 2018, (35):
[8] Disarray at the headquarters: Economists and Central bankers tested by the subprime and the COVID recessions
Louca, Francisco
Abreu, Alexandre
Costa, Goncalo Pessa
[J]. INDUSTRIAL AND CORPORATE CHANGE, 2021, 30 (02) : 273 - 296
[9] Careers in Disarray? COVID-19 and Self-Perceived Employability
Ren, Shuang
Islam, Mohammad Tarikul
Chadee, Doren
[J]. JOURNAL OF CAREER ASSESSMENT, 2024, 32 (02) : 207 - 225
[10] Haemostatic Disarray Following COVID-19 Vaccine - a Case of Acquired Haemophila A
O'Shea, Evelyn
Daly, Orna
Duggan, Cleona
Crowley, Maeve
[J]. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2022, 28

← 1 2 3 4 5 →