Scar tissue to lung cancer; pathways and treatment

被引：4

作者：

Sapalidis, Konstantinos ^{[1
]}

Sardeli, Chrysanthi ^{[2
]}

Pavlidis, Efstathios ^{[1
]}

Koimtzis, Georgios ^{[1
]}

Koulouris, Charilaos ^{[1
]}

Michalopoulos, Nikolaos ^{[1
]}

Mantalovas, Stylianos ^{[1
]}

Tsiouda, Theodora ^{[1
]}

Passos, Ioannis ^{[1
]}

Kosmidis, Christoforos ^{[1
]}

Giannakidis, Dimitrios ^{[1
]}

Surlin, Valeriu ^{[1
]}

Katsaounis, Athanasios ^{[1
]}

Alexandrou, Vyron ^{[1
]}

Amaniti, Aikaterini ^{[3
]}

Zarogoulidis, Paul ^{[1
,2
]}

Huang, Haidong ^{[4
]}

Li, Qiang ^{[4
]}

Mogoanta, Stelian ^{[5
]}

Kesisoglou, Isaac ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Med Sch, Dept Surg 3, Thessaloniki, Greece

[2] Aristotle Univ Thessaloniki, Fac Hlth Sci, Sch Med, Dept Pharmacol & Clin Pharmacol, Thessaloniki, Greece

[3] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Med Sch, Anaisthisiol Dept, Thessaloniki, Greece

[4] Tongji Univ, Shanghai East Hosp, Diagnost & Therapeut Ctr Resp Dis, Shanghai, Peoples R China

[5] Univ Med & Pharm Craiova, Fac Dent, Dept Surg, Craiova, Romania

来源：

JOURNAL OF CANCER | 2019年 / 10卷 / 04期

关键词：

lung cancer; scar tissue; interstitial disease; fibrosis; pathways; IDIOPATHIC PULMONARY-FIBROSIS; EGFR MUTATION DETECTION; LIQUID BIOPSY; DISEASE; PNEUMONITIS; NSCLC; OSIMERTINIB; MECHANISMS; CRIZOTINIB; RESISTANCE;

D O I：

10.7150/jca.30300

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung cancer still remains diagnosed at a late stage although we have novel diagnostic techniques at our disposal. However; for metastatic disease we have novel therapies based on pharmacogenomics. Tumor heterogenity provides us different treatments. There are several reasons for carcinogenesis; fibrosis and scar tissue provides an environment that induces malignancy. In the current review we will try and elucidate the pathways involved from scar tissue to carcinogenesis.

引用

页码：810 / 818

页数：9

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