Zirconium-mediated SN2′ substitution of allylic ethers:: Regio- and stereospecific formation of protected allylic amines

被引：15

作者：

Lalic, G ^{[1
]}

Blum, SA ^{[1
]}

Bergman, RG ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 48期

关键词：

D O I：

10.1021/ja056132f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new zirconium-mediated, regio- and stereospecific SN2′ substitution of allylic ethers with a nitrogen nucleophile has been developed. Cbz-protected amine products were isolated in high yield from reactions with a wide range of Z allylic ethers. A mechanism of the allylic substitution consistent with the results of the kinetics and kinetic isotope effect studies was proposed. Copyright © 2005 American Chemical Society.

引用

页码：16790 / 16791

页数：2

共 49 条

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