Reversing histone methylation

被引：372
|
作者：
Bannister, AJ
Kouzarides, T
机构：
[1] Gurdon Inst, Cambridge CB2 1QN, England
[2] Dept Pathol, Cambridge CB2 1QN, England
来源：
NATURE | 2005年 / 436卷 / 7054期
关键词：
D O I：
10.1038/nature04048
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Histones package DNA, and post-translational modifications of histones can regulate access to DNA. Until recently, histone methylation - unlike all other histone modifications - was considered a permanent mark. The discovery of enzymes that reverse the methylation of lysines and arginines challenges our current thinking on the unique nature of histone methylation, and substantially increases the complexity of histone modification pathways.
引用
收藏
页码：1103 / 1106
页数：4
相关论文
共 50 条
  • [41] Targeting histone methylation in leukemia
    Armstrong, Scott A.
    CANCER RESEARCH, 2013, 73
  • [42] Histone methylation proves reversible
    Yarnell, A
    CHEMICAL & ENGINEERING NEWS, 2005, 83 (18) : 36 - 37
  • [43] Connecting the dots between histone methylation and DNA methylation
    不详
    CELL, 2007, 128 (04) : 633 - 633
  • [44] Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions
    Wu, Hao
    Zhang, Yi
    CELL, 2014, 156 (1-2) : 45 - 68
  • [45] Controlling histone methylation via trans-histone pathways
    Fingerman, Ian M.
    Du, Hai-Ning
    Briggs, Scott D.
    EPIGENETICS, 2008, 3 (05) : 237 - 242
  • [46] Epigenetic regulation: methylation of histone and non-histone proteins
    Fei Lan
    Yang Shi
    Science in China Series C: Life Sciences, 2009, 52 : 311 - 322
  • [47] Epigenetic regulation: methylation of histone and non-histone proteins
    Lan Fei
    Shi Yang
    SCIENCE IN CHINA SERIES C-LIFE SCIENCES, 2009, 52 (04): : 311 - 322
  • [48] Reversal of Histone Methylation: Biochemical and Molecular Mechanisms of Histone Demethylases
    Mosammaparast, Nima
    Shi, Yang
    ANNUAL REVIEW OF BIOCHEMISTRY, VOL 79, 2010, 79 : 155 - 179
  • [49] DNA methylation and histone methylation in the regulation of adult hippocampal neurogenesis
    Kootar, S.
    Sujatha, G.
    Maitra, S.
    Dsouza, L.
    Chakravarty, S.
    Vaidya, V.
    Kumar, A.
    INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 2012, 30 (08) : 654 - 655
  • [50] Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITE
    Du, Jiamu
    Johnson, Lianna M.
    Groth, Martin
    Feng, Suhua
    Hale, Christopher J.
    Li, Sisi
    Vashisht, Ajay A.
    Gallego-Bartolome, Javier
    Wohlschlegel, James A.
    Patel, Dinshaw J.
    Jacobsen, Steven E.
    MOLECULAR CELL, 2014, 55 (03) : 495 - 504
12345