Stereoselective synthesis of 3-hydroxymethyl-D-cyclopentenone, the versatile intermediate for the synthesis of carbocyclic nucleosides

被引：1

作者：

Choi, WJ ^{[1
]}

Moon, HR

Kim, HO

Ko, YM

Kim, HJ

Lee, JA

Lee, KM

Yun, MK

Shin, DH

Chun, MW

Sheen, YY

Kim, K

Jeong, LS

机构：

[1] Ewha Womans Univ, Med Chem Lab, Coll Pharm, Seoul 120750, South Korea

[2] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea

[3] Seoul Natl Univ, Coll Pharm, Seoul, South Korea

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2005年 / 24卷 / 5-7期

关键词：

3-hydroxymethyl-D-cyclopentenone; carbocyclic nucleosides;

D O I：

10.1081/NCN-200061832

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The preparative and stereoselective synthesis (45 - 50% overall yields, >50 g scale) of the key carbasugars 7a-d was achieved from D-ribose via stereoselective Grignard reaction and oxidative rearrangement as key reactions.

引用

页码：611 / 613

页数：3

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