Importance of UDP-glucuronosyltransferase 1A1*6 for irinotecan toxicities in Japanese cancer patients

被引：40
|
作者：
Sai, Kimie [1 ]
Saito, Yoshiro [2 ]
Sakamoto, Hiromi [3 ]
Shirao, Kuniaki [4 ]
Kurose, Koichi [5 ]
Saeki, Mayumi [6 ]
Ozawa, Shogo [7 ]
Kaniwa, Nahoko [5 ]
Hirohashi, Setsuo [8 ]
Saijo, Nagahiro [9 ]
Sawada, Jun-ichi [2 ]
Yoshida, Teruhiko [3 ]
机构：
[1] Natl Inst Hlth Sci, Div Biosignaling, Setagaya Ku, Tokyo 1588501, Japan
[2] Natl Inst Hlth Sci, Dept Biochem & Immunochem, Setagaya Ku, Tokyo 1588501, Japan
[3] Natl Inst Canc Res, Div Genet, Chuo Ku, Tokyo 1040045, Japan
[4] Natl Canc Ctr, Div Internal Med, Chuo Ku, Tokyo 1040045, Japan
[5] Natl Inst Hlth Sci, Div Med Safety Sci, Setagaya Ku, Tokyo 1588501, Japan
[6] Natl Inst Hlth Sci, Project Team Pharmacogenet, Setagaya Ku, Tokyo 1588501, Japan
[7] Natl Inst Hlth Sci, Div Pharmacol, Setagaya Ku, Tokyo 1588501, Japan
[8] Natl Inst Canc Res, Div Pathol, Chuo Ku, Tokyo 1040045, Japan
[9] Natl Canc Ctr Hosp E, Chiba 2778577, Japan
来源：
CANCER LETTERS | 2008年 / 261卷 / 02期
关键词：
UGT1A1; pharmacogenetics; irinotecan; SN-38;
D O I：
10.1016/j.canlet.2007.11.009
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent pharmacogenetic studies on irinotecan have revealed the impact of UDP glucuronosyltransferase (UGT) 1A1*28 on severe irinotecan toxicities. Although the clinical role of UGT1A1*6, which is specifically detected in East Asian patients, in irinotecan toxicities is suggested, clear evidence remains limited. To examine the impact of *6, the association of UGT1A1 genotypes with severe irinotecan toxicities was retrospectively investigated in Japanese cancer patients. A significant *6-dependent increase in the incidence of grade 3 or 4 neutropenia was observed in 49 patients on irinotecan mono-therapy (p = 0.012). This study further clarifies the clinical importance of *6 in irinotecan therapy in East Asians. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：165 / 171
页数：7
相关论文
共 50 条
  • [21] Haplotypes of variants in the UDP-glucuronosyltransferase 1A9 and 1A1 genes
    Innocenti, F
    Liu, WQ
    Chen, PX
    Desai, AA
    Das, S
    Ratain, MJ
    PHARMACOGENETICS AND GENOMICS, 2005, 15 (05): : 295 - 301
  • [22] Fuctional consequences of interindividual variation in human sulfotransferase 1A1 and UDP-glucuronosyltransferase 1A6
    Raftogianis, RB
    DRUG METABOLISM REVIEWS, 2003, 35 : 6 - 6
  • [23] Role of UDP-Glucuronosyltransferase 1A1 in the Metabolism and Pharmacokinetics of Silymarin Flavonolignans in Patients with HCV and NAFLD
    Xie, Ying
    Miranda, Sonia R.
    Hoskins, Janelle M.
    Hawke, Roy L.
    MOLECULES, 2017, 22 (01):
  • [24] Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A1 enzymes
    Hanioka, Nobumitsu
    Tanabe, Natsuko
    Jinno, Hideto
    Tanaka-Kagawa, Toshiko
    Nagaoka, Kenjiro
    Naito, Shinsaku
    Koeda, Akiko
    Narimatsu, Shizuo
    LIFE SCIENCES, 2010, 87 (7-8) : 261 - 268
  • [25] (TA)n UDP-glucuronosyltransferase 1A1 promoter polymorphism in nigerian neonates
    Kaplan, Michael
    Slusher, Tina
    Renbaum, Paul
    Essiet, Dominic F.
    Pam, Sunday
    Levy-Lahad, Ephrat
    Hammerman, Cathy
    PEDIATRIC RESEARCH, 2008, 63 (01) : 109 - 111
  • [26] Prolonged Hyperbilirubinemia in a Neonate with a Novel Mutation in the UDP-glucuronosyltransferase 1A1 Gene
    Mu, Shu-Chi
    Chen, Yi-Ling
    Tsai, Li-Yi
    Shih, Yung-Luen
    Chen, En-Sung
    Huang, Ching-Shan
    NEONATOLOGY, 2016, 109 (03) : 235 - 238
  • [27] Significant Inhibition of UDP-Glucuronosyltransferase (UGT) 1A1 by Plant Flavonoid Alpinetin
    Gao, Chengcheng
    Cao, Yue
    Gao, Xingchun
    Qu, Yan-Qing
    Liu, Hui
    Liu, Huiling
    Wu, Shangnong
    Tu, Yanyang
    Xie, Rui
    LATIN AMERICAN JOURNAL OF PHARMACY, 2012, 31 (09): : 1360 - 1362
  • [28] (TA)n UDP-Glucuronosyltransferase 1A1 Promoter Polymorphism in Nigerian Neonates
    Michael Kaplan
    Tina Slusher
    Paul Renbaum
    Dominic F Essiet
    Sunday Pam
    Ephrat Levy-Lahad
    Cathy Hammerman
    Pediatric Research, 2008, 63 : 109 - 111
  • [29] Hemolysis and bilirubin conjugation in association with UDP-glucuronosyltransferase 1A1 promoter polymorphism
    Kaplan, M
    Hammerman, C
    Rubaltelli, FF
    Vilei, MT
    Levy-Lahad, E
    Renbaum, P
    Vreman, HJ
    Stevenson, DK
    Muraca, M
    HEPATOLOGY, 2002, 35 (04) : 905 - 911
  • [30] Association between neonatal hyperbilirubinemia and UDP-glucuronosyltransferase 1A1 gene polymorphisms
    Kaplan, Michael
    Hammerman, Cathy
    PEDIATRICS INTERNATIONAL, 2013, 55 (02) : 259 - 259
12345