Importance of UDP-glucuronosyltransferase 1A1*6 for irinotecan toxicities in Japanese cancer patients

被引：40
|
作者：
Sai, Kimie [1 ]
Saito, Yoshiro [2 ]
Sakamoto, Hiromi [3 ]
Shirao, Kuniaki [4 ]
Kurose, Koichi [5 ]
Saeki, Mayumi [6 ]
Ozawa, Shogo [7 ]
Kaniwa, Nahoko [5 ]
Hirohashi, Setsuo [8 ]
Saijo, Nagahiro [9 ]
Sawada, Jun-ichi [2 ]
Yoshida, Teruhiko [3 ]
机构：
[1] Natl Inst Hlth Sci, Div Biosignaling, Setagaya Ku, Tokyo 1588501, Japan
[2] Natl Inst Hlth Sci, Dept Biochem & Immunochem, Setagaya Ku, Tokyo 1588501, Japan
[3] Natl Inst Canc Res, Div Genet, Chuo Ku, Tokyo 1040045, Japan
[4] Natl Canc Ctr, Div Internal Med, Chuo Ku, Tokyo 1040045, Japan
[5] Natl Inst Hlth Sci, Div Med Safety Sci, Setagaya Ku, Tokyo 1588501, Japan
[6] Natl Inst Hlth Sci, Project Team Pharmacogenet, Setagaya Ku, Tokyo 1588501, Japan
[7] Natl Inst Hlth Sci, Div Pharmacol, Setagaya Ku, Tokyo 1588501, Japan
[8] Natl Inst Canc Res, Div Pathol, Chuo Ku, Tokyo 1040045, Japan
[9] Natl Canc Ctr Hosp E, Chiba 2778577, Japan
来源：
CANCER LETTERS | 2008年 / 261卷 / 02期
关键词：
UGT1A1; pharmacogenetics; irinotecan; SN-38;
D O I：
10.1016/j.canlet.2007.11.009
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent pharmacogenetic studies on irinotecan have revealed the impact of UDP glucuronosyltransferase (UGT) 1A1*28 on severe irinotecan toxicities. Although the clinical role of UGT1A1*6, which is specifically detected in East Asian patients, in irinotecan toxicities is suggested, clear evidence remains limited. To examine the impact of *6, the association of UGT1A1 genotypes with severe irinotecan toxicities was retrospectively investigated in Japanese cancer patients. A significant *6-dependent increase in the incidence of grade 3 or 4 neutropenia was observed in 49 patients on irinotecan mono-therapy (p = 0.012). This study further clarifies the clinical importance of *6 in irinotecan therapy in East Asians. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：165 / 171
页数：7
相关论文
共 50 条
  • [1] Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model
    Mennillo, Elvira
    Yang, Xiaojing
    Weber, Andre A.
    Maruo, Yoshihiro
    Verreault, Melanie
    Barbier, Olivier
    Chen, Shujuan
    Tukey, Robert H.
    DRUG METABOLISM AND DISPOSITION, 2022, 50 (01) : 33 - 42
  • [2] Genetic polymorphisms of the UDP-glucuronosyltransferase 1A7 gene and irinotecan toxicity in Japanese cancer patients
    Ando, M
    Ando, Y
    Sekido, Y
    Ando, M
    Shimokata, K
    Hasegawa, Y
    JAPANESE JOURNAL OF CANCER RESEARCH, 2002, 93 (05): : 591 - 597
  • [3] INHIBITION OF ERLOTINIB AGAINST UDP-GLUCURONOSYLTRANSFERASE 1A1
    Liu, Y.
    Ramirez, J.
    House, L. K.
    Ratain, M. J.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2009, 85 : S38 - S38
  • [4] Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan
    Innocenti, F
    Undevia, SD
    Iyer, L
    Chen, PX
    Das, S
    Kocherginsky, M
    Karrison, T
    Janisch, L
    Ramírez, J
    Rudin, CM
    Vokes, EE
    Ratain, MJ
    JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (08) : 1382 - 1388
  • [5] Clinical Significance of UDP-Glucuronosyltransferase 1A1*6 for Toxicities of Combination Chemotherapy with Irinotecan and Cisplatin in Gynecologic Cancers A Prospective Multi-Institutional Study
    Takano, Masashi
    Kato, Masafumi
    Yoshikawa, Tomoyuki
    Sasaki, Naoki
    Hirata, Junko
    Furuya, Kenichi
    Takahashi, Michiko
    Yokota, Harushige
    Kino, Nao
    Horie, Koji
    Goto, Tomoko
    Fujiwara, Keiichi
    Ishii, Kenji
    Kikuchi, Yoshihiro
    Kita, Tsunekazu
    ONCOLOGY, 2009, 76 (05) : 315 - 321
  • [6] Evaluation of Inhibition of UDP-Glucuronosyltransferase (UGT) 1A1 by Demethylzeylasteral
    Yu, Ming-Lian
    Lin, Jia-Ji
    Yang, Yue
    Zhang, Wen-Jing
    Bai, Miao-Chun
    Wang, Cong-Min
    Guo, Yue-Ling
    LATIN AMERICAN JOURNAL OF PHARMACY, 2012, 31 (07): : 1067 - 1070
  • [7] UDP-glucuronosyltransferase 1A1*6 and *28 polymorphisms as indicators of initial dose level of irinotecan to reduce risk of neutropenia in patients receiving FOLFIRI for colorectal cancer
    Miyata, Yoshinori
    Touyama, Tetsuo
    Kusumi, Takaya
    Morita, Yoshitaka
    Mizunuma, Nobuyuki
    Taniguchi, Fumihiro
    Manabe, Mitsuaki
    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2016, 21 (04) : 696 - 703
  • [8] UDP-glucuronosyltransferase 1A1*6 and *28 polymorphisms as indicators of initial dose level of irinotecan to reduce risk of neutropenia in patients receiving FOLFIRI for colorectal cancer
    Yoshinori Miyata
    Tetsuo Touyama
    Takaya Kusumi
    Yoshitaka Morita
    Nobuyuki Mizunuma
    Fumihiro Taniguchi
    Mitsuaki Manabe
    International Journal of Clinical Oncology, 2016, 21 : 696 - 703
  • [9] Importance of UDP-Glucuronosyltransferase 1A1 Expression in Skin and Its Induction by UVB in Neonatal Hyperbilirubinemias
    Sumida, Kyohei
    Kawana, Makiko
    Kouno, Emi
    Itoh, Tomoo
    Takano, Shuhei
    Narawa, Tomoya
    Tukey, Robert H.
    Fujiwara, Ryoichi
    MOLECULAR PHARMACOLOGY, 2013, 84 (05) : 679 - 686
  • [10] Bilirubin UDP-glucuronosyltransferase 1A1 gene polymorphisms:: Susceptibility to oxidative damage and cancer?
    Grant, DJ
    Bell, DA
    MOLECULAR CARCINOGENESIS, 2000, 29 (04) : 198 - 204
12345