Cooperative binding of p53 to DNA:: Regulation by protein-protein interactions through a double salt bridge

被引：45

作者：

Dehner, A

Klein, C

Hansen, S

Müller, L

Buchner, J

Schwaiger, M

Kessler, H

机构：

[1] Tech Univ Munich, Dept Chem, D-85747 Garching, Germany

[2] Roche Diagnost GmbH, Pharma Res, D-82372 Penzberg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 33期

关键词：

DNA; mutagenesis; NMR spectroscopy; p53; protein structures;

D O I：

10.1002/anie.200501887

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Mutations in the transcription factor p53 enhance one's predisposition to cancer. Mutational studies show that double salt bridges are key elements for the dimerization of p53, its cooperative binding to DNA, and thus its proper function as a tumor suppressor (see picture). This might explain certain germ-line mutations found in patients with Li-Fraumeni syndrome. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5247 / 5251

页数：5

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