Multi-color stimulated Raman scattering with a frame-to-frame wavelength-tunable fiber-based light source

被引:7
|
作者
Wuerthwein, Thomas [1 ]
Wallmeier, Kristin [1 ]
Brinkmann, Maxmilian [2 ]
Hellwig, Tim [2 ]
Luepken, Niklas M. [1 ]
Lemberger, Nick S. [1 ]
Fallnich, Carsten [1 ,3 ,4 ]
机构
[1] Univ Munster, Inst Appl Phys, Corrensstr 2, D-48149 Munster, Germany
[2] Refined Laser Syst GmbH, Mendelstr 11, D-48149 Munster, Germany
[3] Univ Twente, MESA Inst Nanotechnol, POB 217, NL-7500 AE Enschede, Netherlands
[4] Univ Munster, Cells Motion Interfac Ctr, Munster, Germany
来源
BIOMEDICAL OPTICS EXPRESS | 2021年 / 12卷 / 10期
关键词
OPTICAL PARAMETRIC OSCILLATOR; INTENSITY NOISE; TIMING JITTER; LASERS; MICROSCOPY; SOLITON; REDUCTION; GAIN; BAND;
D O I
10.1364/BOE.436299
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We present multi-color imaging by stimulated Raman scattering (SRS) enabled by an ultrafast fiber-based light source with integrated amplitude modulation and frame-to-frame wavelength tuning. With a relative intensity noise level of -153.7 dBc/Hz at 20.25 MHz the light source is well suited for SRS imaging and outperforms other fiber-based light source concepts for SRS imaging. The light source is tunable in under 5 ms per arbitrary wavelength step between 700 cm(-1) and 3200 cm(-1), which allows for addressing Raman resonances from the fingerprint to the CH-stretch region. Moreover, the compact and environmentally stable system is predestined for fast multi-color assessments of medical or rapidly evolving samples with high chemical specificity, paving the way for diagnostics and sensing outside of specialized laser laboratories. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.
引用
收藏
页码:6228 / 6236
页数:9
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