Breast cancer pathology: The impact of molecular taxonomy on morphological taxonomy

被引：20
|
作者：
Masuda, Shinobu [1 ]
机构：
[1] Nihon Univ, Sch Med, Dept Pathol, Itabashi Ku, Tokyo 1738610, Japan
来源：
PATHOLOGY INTERNATIONAL | 2012年 / 62卷 / 05期
基金：
日本学术振兴会;
关键词：
breast cancer; intrinsic subtype; molecular taxonomy; morphological taxonomy; CARCINOMA IN-SITU; INTERNATIONAL EXPERT CONSENSUS; E-CADHERIN REACTIVITY; LOBULAR CARCINOMA; BASAL-LIKE; APOCRINE CARCINOMAS; PROGNOSTIC-FACTORS; PRIMARY THERAPY; EXPRESSION; FEATURES;
D O I：
10.1111/j.1440-1827.2012.02790.x
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The concept of having an intrinsic subtype, or a molecular taxonomy, lets us clearly recognize that breast cancers have characteristically different patterns of gene expression, thus giving newfound significance to morphological taxonomy. In this review, the concept of the intrinsic subtype is discussed, research questions are introduced to refine the significance of morphological taxonomy, and a corresponding example is presented between microarray analysis and immunohistochemical subtype, or histological taxonomy.
引用
收藏
页码：295 / 302
页数：8
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